Browse Items (9398 total)

Introduction: Positive Airway Pressure (PAP) therapy has been shown to reduce mortality risk in patients with obstructive sleep apnea (OSA), but its effectiveness across different subgroups remains unclear. This study aims to predict mortality based…

This project addresses workflow inefficiencies in the labor and delivery unit (L&D) at Summa Health, focusing on scheduling and resource distribution challenges that lead to significant delays in scheduled C-sections. These delays inconvenience…

Mechanisms underlying dysfunctional cognitive integration of social and emotional behavior following traumatic brain injury (TBI) are poorly understood. We aimed to develop a model to study longitudinal socioemotional behavior after TBI in rats.…

Alzheimer’s disease (AD), the leading cause of dementia and the sixth leading cause of death in the U.S. There is significant interest to develop therapies for the earliest stages of AD. β-amyloid (Aβ) plaque neuropathology is a hall mark of AD.…

Purpose: Obesity is a major contributor to chronic diseases like metabolic syndrome and cardiovascular conditions. In primary care, addressing weight management is crucial to mitigating these comorbidities. This sub analysis, part of a broader…

Focal nodular hyperplasia (FNH) of the liver is a benign hepatic lesion, commonly found in women in their third and fourth decades of life. FNH is hypothesized to arise from a vascular malformation resulting in a hyperplastic response. While FNH is a…

Osteoarthritis (OA) is the most common type of arthritis and a leading cause of disability. Currently, there is no cure for OA. More females develop OA compared to males. However, female mice were found to be protected from trauma-induced…

This case report presents a 30-year-old male patient with ESKD thought to be secondary to atrophic kidney and tubulointerstitial disease, who is currently on the kidney transplant list. His medical history is significant for insulin-dependent…

Integrins are cell-surface proteins that regulate cell growth and brain development. Research shows certain integrins (e.g. αVβ1 and αVβ5) are dysregulated in Alzheimer’s disease (AD), a tauopathy with limited therapeutic treatment. Irisin, a hormone…

Semaphorin 3F (SEMA3F), a class 3 semaphorin protein, is known for a plethora of bodily functions. Other class 3 semaphorins and their receptors have been found to regulate bone metabolism by dysregulating osteoclasts (OC) and/or osteoblast (OB)…

We present a case of a patient with multiple sclerosis misdiagnosed as ischemic stroke, resulting in repeated hospital admissions and delayed treatment. The atypical features of the case resulted in extensive workup consisting of multiple MRIs and a…

One of the many miracles of modern medicine is advances in survival among children with childhood cancer. Notably, children diagnosed with acute lymphoblastic leukemia (ALL) had a survival rate of 92% in the late 2010s compared to less than 60% in…

Background: Acute kidney injury (AKI) is seen in nearly 7% of hospital admissions and 30% of intensive care unit (ICU) admissions. It is associated with significant mortality and several major comorbidities including diabetes, sepsis, and heart…

Low-value care (LVC, services that offer minimal/no clinical benefit), is a focus area of health services research. Excess specialty referrals (XSR) from primary care is an example of LVC. This scoping review examined the drivers and consequences of…

This quality improvement project aims to determine if vaccination education increases vaccination rates among rural geriatric populations who are at a high risk for hospitalization as a result of pneumococcal pneumonia. The primary objective is to…

Background: Patients with head and neck cancer (HNC) face unique treatment-related challenges like dysphagia, dysgeusia, and appetite loss, leading to high rates of malnutrition. Often, patients are recommended placement of a percutaneous endoscopic…

Mammalian thermoregulation is an energetically expensive aspect of homeostasis. The body responds to temperature extremes through activities like sweating and shivering. Lemurs are well known for sunning and huddling to maintain body temperature when…

A 17-year-old female presents with recurrent epigastric pain following the diagnosis of median arcuate ligament syndrome (MALS) confirmed via ultrasound duplex and computed tomography angiography. Subsequent laparoscopic median arcuate ligament…

Background: Insulin autoimmune syndrome is a rare disorder characterized by anti-insulin antibodies which cause hyperinsulinemic hypoglycemia without any prior use of exogenous insulin. We report a case of a patient with hyperinsulinemic hypoglycemia…

Purpose: This article describes the clinical significance of the southern black widow spider (Latrodectus mactans). This includes discussing the spider's basic biology, the common symptoms of black widow spider bites, how healthcare professionals…

Health literacy, particularly in rural America, is a barrier that needs to be addressed in order to improve the overall quality of health amongst rural communities. Lower levels of health literacy are associated with increased hospitalization,…

Patients now have the ability to shop for physicians based on online reviews left on physician rating websites (PRW) by previous patients. In response to this, reputation management companies (RMCs) were created to manage online reviews for…

ATP13A2 is a P5 ATPase involved in lysosomal polyamine transport. Loss of function mutations are associated with multiple progressive neurodegenerative disorders including Parkinson’s disease. In many ATP13A2-related cases cognitive dysfunction…

Hypertension is a national crisis and can lead to cardiovascular issues such as heart failure, heart attack, heart disease, and stroke, as well as kidney disease, vision loss, and metabolic disorders. In rural communities, hypertension can be more…

Global longitudinal stress (GLS) is an advanced imaging technology that allows for the early detection of systolic dysfunction, which is crucial in preventing heart failure. Though GLS has seen limited use in mice models, recent studies have…

Hypertension is a growing concern worldwide, with increasing prevalence rates in both children and adults. Most cases of hypertension are multifactorial, with various genetic, environmental, socioeconomic, and lifestyle influences. However, monogenic…

Purpose: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a class of diabetes mellitus medications that have been a major focus of research over the past decade, and it’s not for their effects on lowering blood sugar. After their release to the…

Developing and implementing new policies for best practices across healthcare settings is a major challenge. Healthcare policies that affect older adults carry a weighted effect not only on patients, but also on caregivers, providers and the…

CT imaging of intervertebral discs (IVDs) is challenging due to the poor X-ray attenuation properties of the annulus fibrosus (AF) and nucleus pulposus (NP). IVD degeneration (IDD) is a leading cause of low back pain, contributing to substantial…

Since genomic sequencing was first developed, it has been the subject of numerous research studies addressing its potential uses, affordability, and ethical implications. While significant progress has been made in these areas in recent years, there…

Northeast Ohio Medical University (NEOMED) has partnered with Salem High School in Salem, Ohio to utilize medical students in the Rural Medical Education Program, with a goal of promoting healthcare-related career paths among rural high school…

This study explores the impact of neighborhood disorder and collective efficacy on health outcomes among individuals with severe and persistent mental illness (SPMI). Using a cross-sectional design with 203 participants, measures included…

Purpose: Artificial intelligence tools with the ability to detect fractures have recently been utilized to decrease the burden of high imaging volumes on radiologists. This study serves to evaluate the utility of the AI software, Rayvolve, in…

Both alcohol and high fat diet consumption can lead to steatosis, or excess fat in the liver. Reversible steatosis can progress to serious irreversible liver disease via increased inflammation and scarring. Bile acids are made in the liver and aid in…

A 52-year-old man presented with sudden bilateral lower extremity weakness, stiffness, dyspnea, and difficulty walking. His history included hypertension, vertigo, and a thymic neoplasm diagnosed in 2019. Physical exam showed increased tone,…

Trafficking protein particle complex subunit 9 (TRAPPC9) is one of the largest TRAPPII complex subunits. This study's purpose is to elucidate the role of TRAPPC9 in osteoblast proliferation, differentiation, and function. Immunohistochemical staining…

This quality improvement project aims to evaluate the impact of developing standardized microalbuminuria screening practices on the rates of up to date screening among rural patients with diabetes. The primary objective is to determine where enhanced…

Objective: Physician review websites (PRWs) enable patients to search for a potential dermatologist based on other patient reviews. These reviews impact a patient's perception and choice of physician. There has been no previous study published in the…

Hidden hearing loss (HHL) is a relatively new disorder that explains hearing loss that is undetectable by traditional audiologic tests. Also known as cochlear synaptopathy, HHL is characterized by the inability to distinguish desired sounds from…

The physiology of cartilage in bats is poorly understood. To elucidate potential novel physiological attributes of these tissues in bats (n=3), this study utilized chondrocytes harvested from limbs in a 2D culture system and tested for their…