Update On Cytomegalovirus Infections Of The Gastrointestinal System In Solid Organ Transplant Recipients

Title

Update On Cytomegalovirus Infections Of The Gastrointestinal System In Solid Organ Transplant Recipients

Creator

Lemonovich T L; Watkins R R

Publisher

Current Infectious Disease Reports

Date

2012
2012-02

Description

Cytomegalovirus (CMV) infection of the gastrointestinal tract is the most common manifestation of tissue-invasive CMV disease, and is a significant cause of morbidity and mortality in the solid organ transplantation (SOT) recipient. In addition to the direct effects of the infection, its indirect effects on allograft function, risk for other opportunistic infections, and mortality are significant in this population. The most common clinical syndromes are esophagitis, colitis, and hepatitis; however, infection can occur anywhere in the gastrointestinal tract. Diagnosis is usually by histopathology or viral culture of tissue specimens; molecular assays also often have a role. Antivirals are the cornerstone of therapy for gastrointestinal tract CMV disease and complications such as recurrent infection and antiviral resistance are not uncommon. Prevention with antiviral prophylaxis or preemptive therapy is important. This review summarizes recent data regarding the clinical manifestations, diagnosis, treatment, and prevention of gastrointestinal tract CMV infection in the SOT population.

Subject

CMV; Cytomegalovirus; Gastrointestinal infection; Infectious Diseases; Solid organ transplant

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

33-40

Issue

1

Volume

14

Citation

Lemonovich T L; Watkins R R, “Update On Cytomegalovirus Infections Of The Gastrointestinal System In Solid Organ Transplant Recipients,” NEOMED Bibliography Database, accessed July 29, 2021, https://neomed.omeka.net/items/show/10704.

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