A Rare Case of Simultaneous Evans Syndrome and Primary Antiphospholipid Syndrome.
Title
A Rare Case of Simultaneous Evans Syndrome and Primary Antiphospholipid Syndrome.
Creator
Patel Bhamini P; Jakob John
Publisher
Cureus
Date
2020
2020-02
Description
Evans Syndrome (ES) is a rare autoimmune disorder that presents with simultaneous or sequential development of autoimmune hemolytic anemia (AIHA), thrombocytopenia, and/or neutropenia. This disease may occur in conjunction with other autoimmune disorders. Primary antiphospholipid syndrome (APS) is a disorder characterized by thrombosis, which can cause life-threatening complications such as fetal demise, strokes, or deep vein thrombosis. A 67-year-old male with type 2 diabetes mellitus, hypertension, and renal insufficiency presented with concomitant ES and APS. His hematological abnormalities began in 2013 after a deep vein thrombosis of the left lower extremity led to a diagnosis of APS and was started on chronic warfarin. In 2014, he was found to have immune thrombocytopenia (ITP) with relapses the following year. Several months later, he was hospitalized and diagnosed with AIHA. In the setting of his previous episodes of ITP and current AIHA, the diagnosis of ES was made. The initial treatment was 100 mg prednisone taper, but rituximab was required to make complete platelet recovery. The severe deterioration and rapid recovery with proper treatment of the patient highlights the importance of a timely diagnosis of ES. Mild thrombocytopenia can be associated with APS; however; severe thrombocytopenia may warrant further investigation for other possible causes. Maintaining ES on the differential diagnosis of patients with APS and thrombocytopenia could enhance health outcomes.
Subject
thrombocytopenia; antiphospholipid syndrome; evans syndrome
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
Journal Article
URL Address
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Pages
e6845-e6845
Issue
2
Volume
12
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
Update Year & Number
March 2020 Update
Citation
Patel Bhamini P; Jakob John, “A Rare Case of Simultaneous Evans Syndrome and Primary Antiphospholipid Syndrome.,” NEOMED Bibliography Database, accessed November 2, 2024, https://neomed.omeka.net/items/show/10963.