A Rare Case of Simultaneous Evans Syndrome and Primary Antiphospholipid Syndrome.

Title

A Rare Case of Simultaneous Evans Syndrome and Primary Antiphospholipid Syndrome.

Creator

Patel Bhamini P; Jakob John

Publisher

Cureus

Date

2020
2020-02

Description

Evans Syndrome (ES) is a rare autoimmune disorder that presents with simultaneous or sequential development of autoimmune hemolytic anemia (AIHA), thrombocytopenia, and/or neutropenia. This disease may occur in conjunction with other autoimmune disorders. Primary antiphospholipid syndrome (APS) is a disorder characterized by thrombosis, which can cause life-threatening complications such as fetal demise, strokes, or deep vein thrombosis. A 67-year-old male with type 2 diabetes mellitus, hypertension, and renal insufficiency presented with concomitant ES and APS. His hematological abnormalities began in 2013 after a deep vein thrombosis of the left lower extremity led to a diagnosis of APS and was started on chronic warfarin. In 2014, he was found to have immune thrombocytopenia (ITP) with relapses the following year. Several months later, he was hospitalized and diagnosed with AIHA. In the setting of his previous episodes of ITP and current AIHA, the diagnosis of ES was made. The initial treatment was 100 mg prednisone taper, but rituximab was required to make complete platelet recovery. The severe deterioration and rapid recovery with proper treatment of the patient highlights the importance of a timely diagnosis of ES. Mild thrombocytopenia can be associated with APS; however; severe thrombocytopenia may warrant further investigation for other possible causes. Maintaining ES on the differential diagnosis of patients with APS and thrombocytopenia could enhance health outcomes.

Subject

thrombocytopenia; antiphospholipid syndrome; evans syndrome

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

Journal Article

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Pages

e6845-e6845

Issue

2

Volume

12

NEOMED College

NEOMED College of Medicine

NEOMED Department

NEOMED Student Publications

Update Year & Number

March 2020 Update

Citation

Patel Bhamini P; Jakob John, “A Rare Case of Simultaneous Evans Syndrome and Primary Antiphospholipid Syndrome.,” NEOMED Bibliography Database, accessed November 28, 2022, https://neomed.omeka.net/items/show/10963.

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