Ischemic heart disease pathophysiology paradigms overview: From plaque activation to microvascular dysfunction.

Title

Ischemic heart disease pathophysiology paradigms overview: From plaque activation to microvascular dysfunction.

Creator

Severino P;D'Amato A;Pucci M;Infusino F;Adamo F;Birtolo LI;Netti L;Montefusco G;Chimenti C;Lavalle C;Maestrini V;Mancone M;Chilian WM;Fedele F

Publisher

International Journal of Molecular Sciences

Date

2020
2020-10-30

Description

Ischemic heart disease still represents a large burden on individuals and health care resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow-limiting obstruction in large-medium sized coronary arteries. However, clinical, angiographic and autoptic findings suggest a multifaceted pathophysiology for ischemic heart disease and just some cases are caused by severe or complicated atherosclerotic plaques. Currently there is no well-defined assessment of ischemic heart disease pathophysiology that satisfies all the observations and sometimes the underlying mechanism to everyday ischemic heart disease ward cases is misleading. In order to better examine this complicated disease and to provide future perspectives, it is important to know and analyze the pathophysiological mechanisms that underline it, because ischemic heart disease is not always determined by atherosclerotic plaque complication. Therefore, in order to have a more complete comprehension of ischemic heart disease we propose an overview of the available pathophysiological paradigms, from plaque activation to microvascular dysfunction.

Subject

atherosclerosis; ion channels; microcirculation; myocardial infarction; coronary blood flow; ischemic heart disease

Format

journalArticle

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Issue

21

Volume

21

ISSN

1422-0067 1422-0067

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Integrative Medical Sciences

Update Year & Number

October 2020 List

Citation

Severino P;D'Amato A;Pucci M;Infusino F;Adamo F;Birtolo LI;Netti L;Montefusco G;Chimenti C;Lavalle C;Maestrini V;Mancone M;Chilian WM;Fedele F, “Ischemic heart disease pathophysiology paradigms overview: From plaque activation to microvascular dysfunction.,” NEOMED Bibliography Database, accessed January 18, 2021, https://neomed.omeka.net/items/show/11329.

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