Ischemic heart disease pathophysiology paradigms overview: From plaque activation to microvascular dysfunction.

Ischemic heart disease pathophysiology paradigms overview: From plaque activation to microvascular dysfunction.

Severino P;D'Amato A;Pucci M;Infusino F;Adamo F;Birtolo LI;Netti L;Montefusco G;Chimenti C;Lavalle C;Maestrini V;Mancone M;Chilian WM;Fedele F

International Journal of Molecular Sciences

2020

2020-10-30

Ischemic heart disease still represents a large burden on individuals and health care resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow-limiting obstruction in large-medium sized coronary arteries. However, clinical, angiographic and autoptic findings suggest a multifaceted pathophysiology for ischemic heart disease and just some cases are caused by severe or complicated atherosclerotic plaques. Currently there is no well-defined assessment of ischemic heart disease pathophysiology that satisfies all the observations and sometimes the underlying mechanism to everyday ischemic heart disease ward cases is misleading. In order to better examine this complicated disease and to provide future perspectives, it is important to know and analyze the pathophysiological mechanisms that underline it, because ischemic heart disease is not always determined by atherosclerotic plaque complication. Therefore, in order to have a more complete comprehension of ischemic heart disease we propose an overview of the available pathophysiological paradigms, from plaque activation to microvascular dysfunction.

atherosclerosis; ion channels; microcirculation; myocardial infarction; coronary blood flow; ischemic heart disease

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1422-0067 1422-0067

NEOMED College of Medicine

Department of Integrative Medical Sciences

October 2020 List