Ischemic heart disease pathophysiology paradigms overview: From plaque activation to microvascular dysfunction.
Title
Ischemic heart disease pathophysiology paradigms overview: From plaque activation to microvascular dysfunction.
Creator
Severino P;D'Amato A;Pucci M;Infusino F;Adamo F;Birtolo LI;Netti L;Montefusco G;Chimenti C;Lavalle C;Maestrini V;Mancone M;Chilian WM;Fedele F
Publisher
International Journal of Molecular Sciences
Date
2020
2020-10-30
Description
Ischemic heart disease still represents a large burden on individuals and health care resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow-limiting obstruction in large-medium sized coronary arteries. However, clinical, angiographic and autoptic findings suggest a multifaceted pathophysiology for ischemic heart disease and just some cases are caused by severe or complicated atherosclerotic plaques. Currently there is no well-defined assessment of ischemic heart disease pathophysiology that satisfies all the observations and sometimes the underlying mechanism to everyday ischemic heart disease ward cases is misleading. In order to better examine this complicated disease and to provide future perspectives, it is important to know and analyze the pathophysiological mechanisms that underline it, because ischemic heart disease is not always determined by atherosclerotic plaque complication. Therefore, in order to have a more complete comprehension of ischemic heart disease we propose an overview of the available pathophysiological paradigms, from plaque activation to microvascular dysfunction.
Subject
atherosclerosis; ion channels; microcirculation; myocardial infarction; coronary blood flow; ischemic heart disease
Identifier
Format
journalArticle
URL Address
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Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Issue
21
Volume
21
ISSN
1422-0067 1422-0067
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Update Year & Number
October 2020 List
Citation
Severino P;D'Amato A;Pucci M;Infusino F;Adamo F;Birtolo LI;Netti L;Montefusco G;Chimenti C;Lavalle C;Maestrini V;Mancone M;Chilian WM;Fedele F, “Ischemic heart disease pathophysiology paradigms overview: From plaque activation to microvascular dysfunction.,” NEOMED Bibliography Database, accessed September 13, 2024, https://neomed.omeka.net/items/show/11329.