Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers.

Title

Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers.

Creator

Tan PPS; Hall D; Chilian WM; Chia YC; Mohd ZS; Lim HM; Kumar DN; Ching SM; Low TY; Noh MFM; Pung Y-F

Publisher

American Journal Of Physiology. Heart And Circulatory Physiology

Date

2021
2021-02-12

Description

MicroRNAs (miRNAs) are small regulatory molecules that are involved in post-transcriptional modifications. These non-coding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body fluids including plasma and urine. Due to their ability to withstand harsh external conditions, exosomal miRNAs possess enormous potentials as non-invasive disease biomarkers for, notably hypertension, whereby exosomal miRNAs have been implicated in its pathophysiological processes. More importantly, alterations in the microenvironment as a result of disease progression can induce active and selective loading of miRNAs into exosomes. In this paper, we first review the mechanisms of miRNA loading into exosomes, followed by the roles of exosomal miRNAs in the development of hypertension; and the potentials of exosomal miRNAs as biomarkers in comparison to other free circulating miRNAs. Finally challenges and future research surrounding exosomal miRNAs will also be discussed. The information synthesized in this review summarizes current knowledge of non-invasive biomarkers for early hypertension diagnosis and for probing therapeutic efficacy.

Subject

extracellular vesicles; small non-coding RNA; clinical biomarker; high blood pressure; microvesicles

Format

journalArticle

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

ISSN

1522-1539 0363-6135

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Integrative Medical Sciences

Update Year & Number

March 2021 List

Citation

Tan PPS; Hall D; Chilian WM; Chia YC; Mohd ZS; Lim HM; Kumar DN; Ching SM; Low TY; Noh MFM; Pung Y-F, “Exosomal microRNAs in the development of essential hypertension and its potential as biomarkers.,” NEOMED Bibliography Database, accessed June 30, 2022, https://neomed.omeka.net/items/show/11591.

Social Bookmarking