Review of fluconazole treatment and prophylaxis for invasive candidiasis in neonates.

Title

Review of fluconazole treatment and prophylaxis for invasive candidiasis in neonates.

Creator

Hornik CD; Bondi DS; Greene NM; Cober MP; John B

Publisher

Journal Of Pediatric Pharmacology & Therapeutics

Date

2021
2021-02-15

Description

Invasive candidiasis accounts for approximately 10% of nosocomial infections in preterm infants, with an incidence of 1% to 4% among neonatal intensive care unit (NICU) admissions and a mortality as high as 20% to 30%. These outcomes warrant improved treatment and prevention strategies for infants at highest risk. The Infectious Diseases Society of America provides guidelines on antifungal medications for the prophylaxis and treatment of candidiasis in NICUs; however, there are still variations in practice on the use of fluconazole for prophylaxis and treatment of invasive candidiasis. This review provides specific information regarding fluconazole activity, pharmacokinetics, and a literature evaluation of dosing strategies and comparisons to other treatments in the neonatal population.

Rights

Copyright. Pediatric Pharmacy Association. All rights reserved. For permissions, email: mhelms@pediatricpharmacy.org 2021.

Format

review

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Pharmacy Practice

Update Year & Number

jan to Aug list 2021

Citation

Hornik CD; Bondi DS; Greene NM; Cober MP; John B, “Review of fluconazole treatment and prophylaxis for invasive candidiasis in neonates.,” NEOMED Bibliography Database, accessed May 21, 2024, https://neomed.omeka.net/items/show/11901.