Lumateperone in the Treatment of Schizophrenia: A Review
Title
Lumateperone in the Treatment of Schizophrenia: A Review
Creator
Robinson GT; Darvesh AS
Publisher
Journal of Medical Sciences at NEOMED
Date
2023
Description
Schizophrenia is a devastating mental illness that afflicts about 1% of the world’s population. This illness distorts a person’s perception of reality and consists of positive symptoms such as hallucinations and delusions, negative symptoms such as inattention and withdrawal, and cognitive deficits. Antipsychotic drugs are primarily used for the pharmacotherapy of schizophrenia. In this article, we provide a succinct review of a recently approved novel antipsychotic, lumateperone. We present an overview and history of schizophrenia, its symptoms, epidemiology, etiology, and pathophysiology. The classification of antipsychotic agents as first and second-generation based on their receptor affinity is discussed. The review focuses on describing the background, development, receptor pharmacology, mechanism of action, pharmacokinetics, clinical trials, adverse effects, therapeutic uses, and future prospects of lumateperone.
Subject
antipsychotic; atypical; lumateperone; schizophrenia; 5-HT2A serotonin receptor
Identifier
n/a
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the Journal of Medical Sciences at NEOMED.
Pages
1-8
Issue
1
Volume
2
NEOMED College
College of Graduate Studies; College of Pharmacy; College of Medicine
NEOMED Department
NEOMED Student Publications
Affiliated Hospital
n/a
Citation
Robinson GT; Darvesh AS, “Lumateperone in the Treatment of Schizophrenia: A Review,” NEOMED Bibliography Database, accessed April 28, 2024, https://neomed.omeka.net/items/show/12288.