L-dopa infusion mode differentially affects corpus striatal dopamine efflux in the presence of reserpine.

Title

L-dopa infusion mode differentially affects corpus striatal dopamine efflux in the presence of reserpine.

Creator

Dluzen D E; Kratko F T Jr

Publisher

Journal of neural transmission. General section

Date

1992
1905-6

Description

In the present experiment we tested the effects of L-DOPA upon dopamine (DA) efflux in vitro from superfused corpus striatal tissue fragments in medium containing reserpine. The purposes of this experiment were first, to evaluate the effects of differing infusion modes of L-DOPA upon DA efflux under conditions in which DA storage capacity has been diminished, and second, to compare this L-DOPA stimulated DA efflux with that of other putative DA secretagogues such as amphetamine and potassium. No differences were obtained in stimulated DA efflux between superfusions performed in the presence or absence of reserpine (10 microM) in the medium when L-DOPA (5 microM) was infused in a continuous (70 minute) mode during the superfusion. In contrast, a continuous infusion of either amphetamine (10 microM) or high potassium (30 mM) resulted in significantly greater stimulated DA efflux in superfusions performed with reserpine in the medium. In addition, when L-DOPA (5 microM) was administered for a brief

Subject

Amphetamine/pharmacology; Animals; Chromatography; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; High Pressure Liquid; Infusions; Intravenous; Levodopa/*pharmacology; Male; Potassium/pharmacology; Rats; Reserpine/*pharmacology; Sprague-Dawley

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

197–207

Issue

3

Volume

89

Citation

Dluzen D E; Kratko F T Jr, “L-dopa infusion mode differentially affects corpus striatal dopamine efflux in the presence of reserpine.,” NEOMED Bibliography Database, accessed April 19, 2021, https://neomed.omeka.net/items/show/3144.

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