P2X receptors in the rat uterine cervix, lumbosacral dorsal root ganglia, and spinal cord during pregnancy.

Title

P2X receptors in the rat uterine cervix, lumbosacral dorsal root ganglia, and spinal cord during pregnancy.

Creator

Papka Raymond E; Hafemeister Jen; Storey-Workley Megan

Publisher

Cell and tissue research

Date

2005
2005-07

Description

ATP, an intracellular energy source, is released from cells during tissue stress, damage, or inflammation. The P2X subtype of the ATP receptor is expressed in rat dorsal root ganglion (DRG) cells, spinal cord dorsal horn, and axons in peripheral tissues. ATP binding to P2X receptors on nociceptors generates signals that can be interpreted as pain from damaged tissue. We have hypothesized that tissue stress or damage in the uterine cervix during late pregnancy and parturition can lead to ATP release and sensory signaling via P2X receptors. Consequently, we have examined sensory pathways from the cervix in nonpregnant and pregnant rats for the presence of purinoceptors. Antiserum against the

Subject

Animals; Blotting; Cervix Uteri/*metabolism; Estrogen Receptor alpha/metabolism; Female; Frozen Sections; Ganglia; Immunohistochemistry; Lumbosacral Region; Pregnancy; Purinergic P2/*metabolism; Purinergic P2X; Rats; Receptors; Spinal Cord/cytology/*metabolism; Spinal/cytology/*metabolism; Sprague-Dawley; Western

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

35–44

Issue

1

Volume

321

Citation

Papka Raymond E; Hafemeister Jen; Storey-Workley Megan, “P2X receptors in the rat uterine cervix, lumbosacral dorsal root ganglia, and spinal cord during pregnancy.,” NEOMED Bibliography Database, accessed March 2, 2021, https://neomed.omeka.net/items/show/3187.

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