Tamoxifen increases methamphetamine-evoked dopamine output from superfused striatal tissue fragments of male mice.

Tamoxifen increases methamphetamine-evoked dopamine output from superfused striatal tissue fragments of male mice.

Willett Matthew C; Dluzen Dean E

Brain research

2004

2004-12

The antiestrogen, tamoxifen (TMX), has been shown to function as a neuroprotectant against the nigrostriatal dopaminergic (NSDA) neurotoxin, methamphetamine (MA), within male mice. In the present report, we examined the effects of a combined infusion of TMX and MA within superfused striatal tissue fragments of male mice as an approach to understand some of the bases for TMX to function as a NSDA neuroprotectant within male mice. In Experiment 1, a coinfusion of TMX at 1, 10, or 100 pg/ml were all equally effective in increasing

Animals; Corpus Striatum/*drug effects/*metabolism; Dopamine Agents/*pharmacology; Dopamine Plasma Membrane Transport Proteins; Dopamine/*metabolism; Drug Synergism; Estrogen Antagonists/*pharmacology; Inbred Strains; Male; Membrane Glycoproteins/metabolism; Membrane Transport Proteins/metabolism; Methamphetamine/*pharmacology; Mice; Nerve Tissue Proteins/metabolism; Tamoxifen/*pharmacology

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