Interleukin IL-12 blocks a specific subset of the transcriptional profile responsive to UVB in epidermal keratinocytes.

Interleukin IL-12 blocks a specific subset of the transcriptional profile responsive to UVB in epidermal keratinocytes.

Molenda Matthew; Mukkamala Lakshmi; Blumenberg Miroslav

Molecular immunology

2006

2006-05

Interleukin-12 (IL-12) is a proinflammatory and immunomodulatory cytokine that plays a critical role it in innate and adaptive immunity by inducing production of interferon-gamma and other cytokines. IL-12 was shown to block the ultraviolet light-induced immunosuppression, important in cancer immunosurveillance, cutaneous allergies and inflammation. To characterize the molecular effects of

*Keratinocytes/metabolism/radiation effects; *Ultraviolet Rays; Cell Culture Techniques; Cells; Cultured; Epidermal Cells; Gene Expression Regulation/drug effects; Genetic/*radiation effects; Humans; Interleukin-12/*genetics/*metabolism/pharmacology; Transcription

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1933–1940

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