Interleukin IL-12 blocks a specific subset of the transcriptional profile responsive to UVB in epidermal keratinocytes.

Title

Interleukin IL-12 blocks a specific subset of the transcriptional profile responsive to UVB in epidermal keratinocytes.

Creator

Molenda Matthew; Mukkamala Lakshmi; Blumenberg Miroslav

Publisher

Molecular immunology

Date

2006
2006-05

Description

Interleukin-12 (IL-12) is a proinflammatory and immunomodulatory cytokine that plays a critical role it in innate and adaptive immunity by inducing production of interferon-gamma and other cytokines. IL-12 was shown to block the ultraviolet light-induced immunosuppression, important in cancer immunosurveillance, cutaneous allergies and inflammation. To characterize the molecular effects of

Subject

*Keratinocytes/metabolism/radiation effects; *Ultraviolet Rays; Cell Culture Techniques; Cells; Cultured; Epidermal Cells; Gene Expression Regulation/drug effects; Genetic/*radiation effects; Humans; Interleukin-12/*genetics/*metabolism/pharmacology; Transcription

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1933–1940

Issue

12

Volume

43

Citation

Molenda Matthew; Mukkamala Lakshmi; Blumenberg Miroslav, “Interleukin IL-12 blocks a specific subset of the transcriptional profile responsive to UVB in epidermal keratinocytes.,” NEOMED Bibliography Database, accessed September 26, 2021, https://neomed.omeka.net/items/show/3702.

Social Bookmarking