Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system.

Title

Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system.

Creator

Dluzen Dean E; Mickley Katherine R

Publisher

Pharmacology, biochemistry, and behavior

Date

2005
2005-01

Description

It has been demonstrated that the gonadal steroid hormone estrogen can exert neuroprotective effects upon the nigrostriatal dopaminergic (NSDA) system against methamphetamine (MA)-induced neurotoxicity in female, but not male, mice. In contrast, the anti-estrogen, tamoxifen (TMX) can function as a NSDA neuroprotectant within both female and male mice. In an attempt to understand these effects of TMX, the effects of this anti-estrogen upon both behavioral and neurochemical indices of NSDA function were examined within female and male mice following treatment with MA. In general, TMX exerted markedly different (bi-directional) effects upon NSDA function between female and male mice. Notably, treatment with TMX resulted in a relative decrease in striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations within male mice and a relative increase in female mice when treated with MA to produce a significant gender difference. Similar effects were obtained for locomotor behaviors related with NSDA function. That is, TMX produced increases in horizontal activity, number of movements and total distance traveled within

Subject

*Sex Characteristics; Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Female; Male; Mice; Motor Activity/drug effects/physiology; Substantia Nigra/*drug effects/metabolism; Tamoxifen/*pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

27–33

Issue

1

Volume

80

Citation

Dluzen Dean E; Mickley Katherine R, “Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system.,” NEOMED Bibliography Database, accessed September 23, 2021, https://neomed.omeka.net/items/show/3760.

Social Bookmarking