Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system.
Title
Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system.
Creator
Dluzen Dean E; Mickley Katherine R
Publisher
Pharmacology, biochemistry, and behavior
Date
2005
2005-01
Description
It has been demonstrated that the gonadal steroid hormone estrogen can exert neuroprotective effects upon the nigrostriatal dopaminergic (NSDA) system against methamphetamine (MA)-induced neurotoxicity in female, but not male, mice. In contrast, the anti-estrogen, tamoxifen (TMX) can function as a NSDA neuroprotectant within both female and male mice. In an attempt to understand these effects of TMX, the effects of this anti-estrogen upon both behavioral and neurochemical indices of NSDA function were examined within female and male mice following treatment with MA. In general, TMX exerted markedly different (bi-directional) effects upon NSDA function between female and male mice. Notably, treatment with TMX resulted in a relative decrease in striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations within male mice and a relative increase in female mice when treated with MA to produce a significant gender difference. Similar effects were obtained for locomotor behaviors related with NSDA function. That is, TMX produced increases in horizontal activity, number of movements and total distance traveled within
Subject
*Sex Characteristics; Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Female; Male; Mice; Motor Activity/drug effects/physiology; Substantia Nigra/*drug effects/metabolism; Tamoxifen/*pharmacology
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Dluzen Dean E; Mickley Katherine R, “Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system.,” NEOMED Bibliography Database, accessed January 18, 2025, https://neomed.omeka.net/items/show/3760.