Non-receptor activators of heterotrimeric G-protein signaling (AGS proteins).

Title

Non-receptor activators of heterotrimeric G-protein signaling (AGS proteins).

Creator

Cismowski Mary J

Publisher

Seminars in cell & developmental biology

Date

2006
2006-06

Description

G-protein coupled receptor (GPCR) signaling represents one of the most conserved and ubiquitous means in mammalian cells for transferring information across the plasma membrane to the intracellular environment. Heterotrimeric G-protein subunits play key roles in transducing these signals, and intracellular regulators influencing the activation state and interaction of these subunits regulate the extent and duration of GPCR signaling. One class of intracellular regulator, the non-receptor activators of G-protein signaling (or AGS proteins), are the major focus of this review. AGS proteins provide a basis for understanding the function of heterotrimeric G-proteins in both GPCR-driven and GPCR independent cellular signaling pathways.

Subject

*Signal Transduction; Animals; Biological; G-Protein-Coupled/*metabolism; Heterotrimeric GTP-Binding Proteins/*metabolism; Humans; Models; Receptors

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

334–344

Issue

3

Volume

17

Citation

Cismowski Mary J, “Non-receptor activators of heterotrimeric G-protein signaling (AGS proteins).,” NEOMED Bibliography Database, accessed May 24, 2024, https://neomed.omeka.net/items/show/3783.