Chronic lymphocytic leukemia-associated membranous glomerulopathy: remission with fludarabine.

Chronic lymphocytic leukemia-associated membranous glomerulopathy: remission with fludarabine.

Butty H; Asfoura J; Cortese F; Doyle M; Rutecki G

American journal of kidney diseases : the official journal of the National Kidney Foundation

1999

1999-02

In some individuals, chronic lymphocytic leukemia (CLL) may be associated with glomerular disease from membranous nephropathy with resultant nephrotic syndrome. CLL is characterized by abnormal immunoregulation with a malignant clonal proliferation of lymphocytes. The association between the abnormal clone and nephrotic syndrome is suggested in some cases by the remission of proteinuria with a reduction in abnormal lymphocyte number after treatment with antineoplastic agents. For the first time, we describe a patient with CLL and associated membranous glomerulopathy whose nephrotic syndrome remitted after treatment with fludarabine, a new purine analogue used in the treatment of refractory CLL.

Antineoplastic Agents/*therapeutic use; B-Cell/*complications; Biopsy; Chronic; Female; Glomerulonephritis; Humans; Kidney/pathology; Leukemia; Lymphocytic; Membranous/diagnosis/*drug therapy/etiology; Vidarabine/*analogs & derivatives/therapeutic use

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

E8–E8

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