The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus.

Title

The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus.

Creator

Ko G Y; Brown-Croyts L M; Teyler T J

Publisher

Brain research bulletin

Date

1997
1905-06

Description

The effects of phenobarbital, phenytoin, and valproic acid on pharmacologically isolated NMDA-EPSP, AMPA-EPSP, and GABA-IPSPs were examined in rat hippocampal slices. Phenobarbital (0.05 mg/ml) had no effect on the NMDA-EPSP, but decreased the slope of the AMPA-EPSP by 13.4% and facilitated the GABA-IPSP slope by 77.12%. Phenytoin (0.02 mg/ml) had no effects on the NMDA-EPSP, AMPA-EPSP, or

Subject

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*pharmacology; Animals; Anticonvulsants/*pharmacology; Electrophysiology; gamma-Aminobutyric Acid/*pharmacology; Hippocampus/*drug effects/physiology; Inbred Strains; Male; N-Methylaspartate/*pharmacology; Phenobarbital/pharmacology; Phenytoin/pharmacology; Rats; Valproic Acid/pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

297–302

Issue

4

Volume

42

Citation

Ko G Y; Brown-Croyts L M; Teyler T J, “The effects of anticonvulsant drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the rat hippocampus.,” NEOMED Bibliography Database, accessed May 6, 2021, https://neomed.omeka.net/items/show/3926.

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