Mild acidic pH inhibition of the major pathway of herpes simplex virus entry into HEp-2 cells.

Title

Mild acidic pH inhibition of the major pathway of herpes simplex virus entry into HEp-2 cells.

Creator

Rosenthal K S; Killius J; Hodnichak C M; Venetta T M; Gyurgyik L; Janiga K

Publisher

The Journal of general virology

Date

1989
1989-04

Description

Penetration of the KOS strain of herpes simplex virus type 1 (HSV-1) and the MS and 333 strains of herpes simplex virus type 2 (HSV-2) into HEp-2 cells at pH 6.3 was at least 100-fold less efficient than at pH 7.4. Penetration of two low passage clinical isolates was completely blocked at pH 6.3. The syncytium-forming

Subject

Animals; Cell Line; Electron; Electrophoresis; Endocytosis; Glycoproteins/analysis; Glycosylation; Humans; Hydrogen-Ion Concentration; Microscopy; Polyacrylamide Gel; Simplexvirus/*physiology/ultrastructure; Temperature; Time Factors; Vero Cells; Viral Proteins/analysis/metabolism

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

857–867

Volume

70 ( Pt 4)

Citation

Rosenthal K S; Killius J; Hodnichak C M; Venetta T M; Gyurgyik L; Janiga K, “Mild acidic pH inhibition of the major pathway of herpes simplex virus entry into HEp-2 cells.,” NEOMED Bibliography Database, accessed October 19, 2021, https://neomed.omeka.net/items/show/4433.

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