Mild acidic pH inhibition of the major pathway of herpes simplex virus entry into HEp-2 cells.

Mild acidic pH inhibition of the major pathway of herpes simplex virus entry into HEp-2 cells.

Rosenthal K S; Killius J; Hodnichak C M; Venetta T M; Gyurgyik L; Janiga K

The Journal of general virology

1989

1989-04

Penetration of the KOS strain of herpes simplex virus type 1 (HSV-1) and the MS and 333 strains of herpes simplex virus type 2 (HSV-2) into HEp-2 cells at pH 6.3 was at least 100-fold less efficient than at pH 7.4. Penetration of two low passage clinical isolates was completely blocked at pH 6.3. The syncytium-forming

Animals; Cell Line; Electron; Electrophoresis; Endocytosis; Glycoproteins/analysis; Glycosylation; Humans; Hydrogen-Ion Concentration; Microscopy; Polyacrylamide Gel; Simplexvirus/*physiology/ultrastructure; Temperature; Time Factors; Vero Cells; Viral Proteins/analysis/metabolism

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857–867

70 ( Pt 4)