A case of Riedel's thyroiditis treated with tamoxifen: another successful outcome.

A case of Riedel's thyroiditis treated with tamoxifen: another successful outcome.

Jung Yiechul J; Schaub Carl R; Rhodes Ronald; Rich Frank A; Muehlenbein Stephen J

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

2004

2004-12

OBJECTIVE: To report a case of Riedel's thyroiditis, which was successfully treated with tamoxifen. METHODS: We present the clinical, laboratory, and imaging findings and describe the clinical course of a patient with Riedel's thyroiditis. RESULTS: A 40-year-old woman presented with hypothyroidism and a large goiter, which was unresponsive to hormone replacement therapy. Magnetic resonance imaging confirmed the presence of an enlarged thyroid gland, more pronounced on the right than on the left. The patient had progressive discomfort attributable to compressive symptoms in the neck. Surgical exploration of the neck disclosed a hard, immobile thyroid mass, which could not be resected because of adherence to surrounding structures. Biopsy of the thyroid and of the muscles of the neck revealed Riedel's thyroiditis. Treatment with tamoxifen, in a dosage of 20 mg twice a day for more than 1(1/2) years, completely resolved the neck mass (substantiated by follow-up magnetic resonance imaging) and relieved the signs and symptoms of compression of the neck. CONCLUSION: Tamoxifen treatment is effective in resolving the mass and compression in Riedel's thyroiditis.

Adult; Female; Humans; Magnetic Resonance Imaging; Goiter/*drug therapy/pathology; Hypothyroidism/drug therapy/pathology; Tamoxifen/*administration & dosage; Thyroiditis/*drug therapy/pathology; Antineoplastic Agents; Hormonal/*administration & dosage

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483–486

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