Effect of serotonin depletion by p-chlorophenylalanine upon discriminative behaviours.

Effect of serotonin depletion by p-chlorophenylalanine upon discriminative behaviours.

Schechter M D

General pharmacology

1991

1905-6

1. Para-chlorophenylalanine (p-CPA), a competitive inhibitor of the serotonin (5-HT) synthesis enzyme tryptophan hydroxylase, was administered to rats at a dosage (100 mg/kg daily for 3 days) that depletes 5-HT. 2. Different groups of these rats were previously trained to discriminate the interoceptive stimuli produced by amphetamine, cathinone, 3,4-methylenedioxymethamphetamine (MDMA),

Male; Animals; Rats; Dopamine/physiology; Brain Chemistry/drug effects; Central Nervous System Stimulants/pharmacology; Discrimination (Psychology)/*drug effects; Serotonin/*physiology; Fenclonine/*pharmacology; Serotonin Antagonists/*pharmacology; Inbred Strains

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

889–893

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