Role of Serotonin in Alzheimer's Disease.

Title

Role of Serotonin in Alzheimer's Disease.

Creator

Geldenhuys Werner I; Van der Schyf Cornelis I

Publisher

CNS Drugs

Date

2011
2011-09

Description

Mounting evidence accumulated over the past few years indicates that the neurotransmitter serotonin plays a significant role in cognition. As a drug target, serotonin receptors have received notable attention due in particular to the role of several serotonin-receptor subclasses in cognition and memory. The intimate anatomical and neurochemical association of the serotonergic system with brain areas that regulate memory and learning has directed current drug discovery programmes to focus on this system as a major ther- apeutic drug target. Thus far, none of these programmes has yielded un- ambiguous data that suggest that any of the new drug entities possesses disease-modifying properties, and significantly more research in this promis- ing area of investigation is required. Compounds are currently being in- vestigated for activity against serotonin 5-HT1, 5-HT4 and 5-HT6 receptors. This review concludes that most work done in the development of selective serotonin receptor ligands is in the pre-clinical or early clinical phase. Also, while many of these compounds will likely find application as adjuvant therapy in the symptomatic treatment of Alzheimer's disease, there are currently only a few drug entities with activity against serotonin receptors that may offer the potential to alter the progression of the disease. [ABSTRACT FROM AUTHOR]

Subject

ALZHEIMER'S disease treatment; COGNITION; MEMORY; NEUROTRANSMITTERS; SEROTONIN

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

765–781

Issue

9

Volume

25

Citation

Geldenhuys Werner I; Van der Schyf Cornelis I, “Role of Serotonin in Alzheimer's Disease.,” NEOMED Bibliography Database, accessed March 3, 2021, https://neomed.omeka.net/items/show/5738.

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