Vancomycin Combined with Piperacillin-Tazobactam Increases the Risk for Acute Kidney Injury.

Vancomycin Combined with Piperacillin-Tazobactam Increases the Risk for Acute Kidney Injury.

Watkins Richard R

Infectious Disease Alert

2017

2017-03

The article comments on the retrospective cohort study "Risk of acute kidney injury in patients on concomitant vancomycin and piperacillin-tazobactam compared to those on vancomycin and cefepime" by B. Navalkele and colleagues. The study found that vancomycin paired with piperacillin-tazobactam increases the risk of acute kidney injury. It recommends clinicians to weigh the risks and benefits of vancomycin and piperacillin-tazobactam given the onset of acute kidney injury.

Antibiotics; Drug Interactions; Kidney Failure; Drug Therapy; Vancomycin; Ampicillin – Therapeutic Use; Vancomycin – Therapeutic Use; Acute – Risk Factors; Cefepime Hydrochloride – Therapeutic Use; Combination – Adverse Effects; Lactam – Adverse Effects

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