Circulating NT-proBNP but not soluble corin levels were associated with preeclampsia in pregnancy-associated hypertension.

Title

Circulating NT-proBNP but not soluble corin levels were associated with preeclampsia in pregnancy-associated hypertension.

Creator

Kumari Meera; Kovach Tracy; Sheehy Brendan; Zabell Allyson; Morales Rommel; Moodley Sangithan Jules; Shah Yogesh G; Maroo Praful V; Maroo Anjli P; Tang W H Wilson

Publisher

Clinical biochemistry

Date

2019
2019-03

Description

BACKGROUND: Corin is a serine protease known to convert B-type natriuretic peptide (BNP) prohormone into BNP and its amino-terminal fragment (NT-proBNP). In mice lacking corin, high blood pressure and proteinuria were found at late gestational stages, with associated delayed trophoblast invasion and impaired spiral artery remodeling in the uterus. We hypothesize that both NT-proBNP and soluble corin elevation predict the presence of preeclampsia in pregnant patients with hypertension. METHODS: We prospectively enrolled 149 pregnant women with a history of chronic hypertension or gestational hypertension presenting at a tertiary-care hospital. We compared plasma NT-proBNP and soluble corin concentrations based on their preeclamptic status. RESULTS: In our study cohort, 62 patients with preeclampsia had lower gestational age than 87 patients without preeclampsia (33.3+/-3 versus 36.6+/-3weeks; P<.001), otherwise the baseline characteristics were similar. We observed higher NT-proBNP concentrations in patients with preeclampsia compared to those without preeclampsia (304.3 [96.34, 570.4] vs. 60.8 [35.61, 136.8] ng/L, P<.001), with no differences between chronic and gestational hypertension. However, the concentration of corin was not statistically different between the two groups (1756 [1214, 2133] vs. 1571 [1171, 1961] ng/L, P=.1087). ROC curve analysis demonstrated stronger predictive value of NT-proBNP compared to soluble corin in predicting the presence of preeclampsia in our study population (AUC 0.7406 vs. 0.5789, P<.0001). CONCLUSION: While corin may contribute to mechanistic underpinnings of the development of preeclampsia in animal models, soluble corin likely has no diagnostic role in human pregnancies for preeclampsia beyond natriuretic peptide levels.

Subject

NT-proBNP; Corin; Preeclampsia

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

NEOMED College

NEOMED College of Medicine

NEOMED Department

NEOMED Student Publications

Citation

Kumari Meera; Kovach Tracy; Sheehy Brendan; Zabell Allyson; Morales Rommel; Moodley Sangithan Jules; Shah Yogesh G; Maroo Praful V; Maroo Anjli P; Tang W H Wilson, “Circulating NT-proBNP but not soluble corin levels were associated with preeclampsia in pregnancy-associated hypertension.,” NEOMED Bibliography Database, accessed February 27, 2021, https://neomed.omeka.net/items/show/6269.

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