Omadacycline: A novel tetracycline derivative with oral and intravenous formulations.

Title

Omadacycline: A novel tetracycline derivative with oral and intravenous formulations.

Creator

Watkins Richard R; Deresinski Stan

Publisher

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Date

2019
2019-03

Description

Omadacycline, an aminomethylcycline, is a novel member of the tetracycline class of antibiotics. It has received approval by the U.S. Food and Drug Administration (FDA) for treatment of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSIs) and is available in both oral and intravenous formulations. It is also being evaluated in clinical trials for the treatment of cystitis and pyelonephritis. The omadacycline molecule was designed to overcome tetracycline resistance and has broad spectrum activity that includes gram-positive bacteria, gram-negative bacteria, anaerobes, atypicals, and other drug-resistant strains like methicillin-resistant Staphylococcus aureus (MRSA), as well as Yersinia pestis and Bacillus anthracis, organisms of biodefense interest. Omadacycline has minimal drug-drug pharmacokinetic interactions and a favorable safety profile, with the most common adverse events being gastrointestinal symptoms.

Subject

antimicrobial resistance; pneumonia; antibiotic; ABSSSI; omadacycline

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Citation

Watkins Richard R; Deresinski Stan, “Omadacycline: A novel tetracycline derivative with oral and intravenous formulations.,” NEOMED Bibliography Database, accessed April 16, 2021, https://neomed.omeka.net/items/show/6291.

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