Serum procalcitonin in the diagnosis and management of intra-abdominal infections

Title

Serum procalcitonin in the diagnosis and management of intra-abdominal infections

Creator

Watkins R R; Lemonovich T L

Publisher

Expert Review of Anti-Infective Therapy

Date

2012
2012-02

Description

The biomarker procalcitonin (PCT) has been used to diagnose and monitor a number of clinically significant infections. Serum levels of PCT are often increased in the presence of bacterial and fungal infections but not viral infections or noninfectious inflammation. Intra-abdominal infections (IAIs) are serious conditions that pose difficult challenges to physicians and the healthcare system. Researchers have evaluated PCT in the management of IAIs, both for diagnosis and for guiding antibiotic therapy. The studies have produced mixed results, leading to controversy on the utility of PCT in IAIs. PCT appears to be most useful in diagnosing postoperative infections and necrotizing pancreatitis. This review aims to summarize these data, explore the pathophysiology of PCT in sepsis from IAIs, discuss the strengths and weaknesses of PCT monitoring in IAIs, and provide guidance for the interpretation of PCT levels.

Subject

acute; anti-thymocyte globulin; antibiotic-therapy; antibiotic-therapy; appendicitis; c-reactive protein; critically-ill patients; intensive-care units; international multicenter; liver-transplantation; liver-transplantation; major abdominal-surgery; pancreatitis; peritonitis; Pharmacology & Pharmacy; procalcitonin; sepsis; spontaneous bacterial

Identifier

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

197-205

Issue

2

Volume

10

Citation

Watkins R R; Lemonovich T L, “Serum procalcitonin in the diagnosis and management of intra-abdominal infections,” NEOMED Bibliography Database, accessed March 5, 2021, https://neomed.omeka.net/items/show/7532.

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