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Tags: Hematopoietic Stem Cell Transplantation

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Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration.

The induction of spongiform myeloencephalopathy by murine leukemia viruses is mediated primarily by infection of central nervous system (CNS) microglia. In this regard, we have previously shown that CasBrE-induced disease requires late, rather than…

Tags: *Gene Transfer Techniques, *Genes, *Microglia/cytology, *Stem Cells/cytology, 1999, Animals, Cell Line, env, Hematopoietic Stem Cell Transplantation, Journal of virology, Lynch W P, Mice, Nerve Degeneration, Retroviridae Infections/pathology/*virology, Retroviridae/genetics/*physiology, Sharpe A H, Snyder E Y

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