Methamphetamine Produces Subsequent Reductions In Running Time To Exhaustion In Mice

Title

Methamphetamine Produces Subsequent Reductions In Running Time To Exhaustion In Mice

Creator

Kalinski M I; Dluzen D E; Stadulis R

Publisher

Brain Research

Date

2001
2001-12

Description

Treatment with methamphetamine (MA - 20 mg/kgx4 i.p. at 2-h intervals) or its vehicle at 7 days prior to tests of running time to exhaustion were evaluated in 60-day-old CD-1 male mice. Pre-treatment running times were not significantly different between the two groups. MA resulted in significantly decreased running times to exhaustion compared to vehicle-treated controls and a significant reduction in corpus striatal dopamine and DOPAC but not norepinephrine. No statistically significant differences in catecholamines were obtained within the hypothalamus, or left ventricle of the heart, nor were body weights significantly different between these groups. The data show that a regimen of MA, which results in an approximate 90% depletion of striatal DA. produces a reduction in running time to exhaustion. (C) 2001 Elsevier Science B.V. All rights reserved.

Subject

brain; catecholamine; dopaminergic activity; exercise; fatigue; left ventricle; mechanisms; metabolism; Neurosciences & Neurology; nigrostriatal; performance; physical exercise; rats; responses; serotonin

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

160-164

Issue

1

Volume

921

Citation

Kalinski M I; Dluzen D E; Stadulis R, “Methamphetamine Produces Subsequent Reductions In Running Time To Exhaustion In Mice,” NEOMED Bibliography Database, accessed January 26, 2021, https://neomed.omeka.net/items/show/10393.

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