Methamphetamine Produces Subsequent Reductions In Running Time To Exhaustion In Mice

Methamphetamine Produces Subsequent Reductions In Running Time To Exhaustion In Mice

Kalinski M I; Dluzen D E; Stadulis R

Brain Research

2001

2001-12

Treatment with methamphetamine (MA - 20 mg/kgx4 i.p. at 2-h intervals) or its vehicle at 7 days prior to tests of running time to exhaustion were evaluated in 60-day-old CD-1 male mice. Pre-treatment running times were not significantly different between the two groups. MA resulted in significantly decreased running times to exhaustion compared to vehicle-treated controls and a significant reduction in corpus striatal dopamine and DOPAC but not norepinephrine. No statistically significant differences in catecholamines were obtained within the hypothalamus, or left ventricle of the heart, nor were body weights significantly different between these groups. The data show that a regimen of MA, which results in an approximate 90% depletion of striatal DA. produces a reduction in running time to exhaustion. (C) 2001 Elsevier Science B.V. All rights reserved.

brain; catecholamine; dopaminergic activity; exercise; fatigue; left ventricle; mechanisms; metabolism; Neurosciences & Neurology; nigrostriatal; performance; physical exercise; rats; responses; serotonin

Journal Article or Conference Abstract Publication

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