Prolactin Stimulates Dopamine Release From The Rat Corpus Striatum In The Absence Of Extracellular Calcium

Prolactin Stimulates Dopamine Release From The Rat Corpus Striatum In The Absence Of Extracellular Calcium

Laping N J; Dluzen D E; Ramirez V D

Neuroscience Letters

1991

1991-12

Prolactin (PRL) increased basal dopamine (DA) release and attenuated amphetamine (AMPH)-stimulated DA release in vitro from rat corpus striatum in a concentration-dependent manner with 10(-5) M PRL being the most effective. The effects of PRL on DA release were enhanced in the absence of extracellular calcium. PRL at 10(-5) M did not alter the DA post-superfusion content of the striatal tissue. These results indicate that the stimulatory effect of PRL on basal DA release does not require extra-cellular calcium and the inhibitory effect on AMPH-stimulated DA release is not due to depletion of DA stores.

amphetamine; behavior; binding-sites; brain; calcium; cerebrospinal-fluid; corpus striatum; dopamine; hypothalamus; in-vitro; Neurosciences & Neurology; prolactin; rat

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