New Biomaterial As A Promising Alternative To Silicone Breast Implants

Title

New Biomaterial As A Promising Alternative To Silicone Breast Implants

Creator

Lim G T; Valente S A; Hart-Spicer C R; Evancho-Chapman M M; Puskas J E; Horne W I; Schmidt S P

Publisher

Journal of the Mechanical Behavior of Biomedical Materials

Date

2013
2013-05

Description

One in eight American women develops breast cancer. Of the many patients requiring mastectomy yearly as a consequence, most elect some form of breast reconstruction. Since 2006, only silicone breast implants have been approved by the FDA for the public use. Unfortunately, over one-third of women with these implants experience complications as a result of tissue-material biocompatibility issues, which may include capsular contracture, calcification, hematoma, necrosis and implant rupture. Our group has been working on developing alternatives to silicone. Linear triblock poly(styrene-b-isobutylene-b-styrene) (SIBS) polymers are self-assembling nanostructured thermoplastic rubbers, already in clinical practice as drug eluting stent coatings. New generations with a branched (arborescent or dendritic) polyisobutylene core show promising potential as a biomaterial alternative to silicone rubber. The purpose of this pre-clinical research was to evaluate the material-tissue interactions of a new arborescent block copolymer (TPE1) in a rabbit implantation model compared to a linear SIBS (SIBSTAR 103T) and silicone rubber. This study is the first to compare the molecular weight and molecular weight distribution, tensile properties and histological evaluation of arborescent SIBS-type materials with silicone rubber before implantation and after explantation. (C) 2013 Elsevier Ltd. All rights reserved.

Subject

arborescent; biocompatibility; Biopolymers; block-copolymers; Breast implants; elastomers; Engineering; Histological study; in-vivo; Materials Science; mechanical-properties; polyisobutylene-based biomaterials; polystyrene; prostheses; rupture; SIBS; thermoplastic; women

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

47-56

Volume

21

Citation

Lim G T; Valente S A; Hart-Spicer C R; Evancho-Chapman M M; Puskas J E; Horne W I; Schmidt S P, “New Biomaterial As A Promising Alternative To Silicone Breast Implants,” NEOMED Bibliography Database, accessed December 8, 2021, https://neomed.omeka.net/items/show/10762.

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