The short-term effect of a single lapse in anti-vascular endothelial growth factor treatment for diabetic macular edemawithin routine clinical practice.

Title

The short-term effect of a single lapse in anti-vascular endothelial growth factor treatment for diabetic macular edemawithin routine clinical practice.

Creator

Yalamanchili SP; Maatouk CM; Enwere DU; Conti TF; Hom GL; Briskin IN; Greenlee TE; Babiuch AS; Singh RP

Publisher

American Journal of Ophthalmology

Date

2020
2020-07-05

Description

PURPOSE: Diabetic macular edema (DME) is a leading cause of vision loss in diabetics. Anti-vascular endothelial growth factor (VEGF) therapy has been shown to be an effective treatment option for DME, although the injections are costly and require frequent visits which increases the risk for unintended treatment lapses. The aim of this study is to characterize the effects of an unintended treatment lapse in patients with DME undergoing anti-VEGF therapy. DESIGN: Retrospective, comparative case series. METHODS: This retrospective chart review compared patients seen in a multicenter institutional practice with DME exhibiting an un-intended minimum three-month lapse in anti-VEGF treatment, with a control group of DME patients receiving regular anti-VEGF treatment without lapses. The primary outcome was difference in central subfield thickness (CST) between the control group and the treatment lapse group at 6 months following treatment lapse. RESULTS: A total of 164 patients were evaluated, 82 patients in the treatment lapse group and 82 patients in the control group. The average age was 65 years, and the average lapse in treatment was 6.2 ± 3.5 months (range 3-24 months). Comparison of data between the lapse and control groups revealed no significant differences in CST respectively [(359.9±108.3 μm), (335.4±94.6 μM)], p=0.066 or in visual acuity (VA) respectively [(66.5±14.3), (68.9±14.5)], p=0.136. Limitations included a relatively small sample size, retrospective nature, and only a single lapse being evaluated. CONCLUSIONS: An un-intended, single, relatively short-term lapse in anti-VEGF treatment in patients with DME did not appear to result in significant anatomic or visual compromise upon resumption of regular follow-up and treatment.

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

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ISSN

1879-1891 0002-9394 0002-9394

NEOMED College

NEOMED College of Medicine

NEOMED Department

NEOMED Student Publications

Update Year & Number

August 2020 List

Citation

Yalamanchili SP; Maatouk CM; Enwere DU; Conti TF; Hom GL; Briskin IN; Greenlee TE; Babiuch AS; Singh RP, “The short-term effect of a single lapse in anti-vascular endothelial growth factor treatment for diabetic macular edemawithin routine clinical practice.,” NEOMED Bibliography Database, accessed January 27, 2021, https://neomed.omeka.net/items/show/11238.

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