Does birth weight affect neonatal body weight, growth, and physiology in an animal model?

Title

Does birth weight affect neonatal body weight, growth, and physiology in an animal model?

Creator

Adjerid K; Mayerl CJ; Gould FDH; Edmonds CE; Stricklen BM; Bond LE; German RZ

Publisher

PLOS One

Date

2021
1905-07

Description

Infant birth weight affects neuromotor and biomechanical swallowing performance in infant pig models. Preterm infants are generally born low birth weight and suffer from delayed development and neuromotor deficits. These deficits include critical life skills such as swallowing and breathing. It is unclear whether these neuromotor and biomechanical deficits are a result of low birth weight or preterm birth. In this study we ask: are preterm infants simply low birth weight infants or do preterm infants differ from term infants in weight gain and swallowing behaviors independent of birth weight? We use a validated infant pig model to show that preterm and term infants gain weight differently and that birth weight is not a strong predictor of functional deficits in preterm infant swallowing. We found that preterm infants gained weight at a faster rate than term infants and with nearly three times the variation. Additionally, we found that the number of sucks per swallow, swallow duration, and the delay of the swallows relative to the suck cycles were not impacted by birth weight. These results suggest that any correlation of developmental or swallowing deficits with reduced birth weight are likely linked to underlying physiological immaturity of the preterm infant.

Subject

PREMATURE infants; BIRTH weight; BODY weight; DEGLUTITION; PHYSIOLOGY; UMBILICAL cord clamping; WEIGHT gain; WEIGHT in infancy

Format

journalArticle

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

e0246954

Issue

2

Volume

16

ISSN

1932-6203

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Anatomy & Neurobiology
NEOMED Postdoc Publications

Update Year & Number

March 2021 List

Citation

Adjerid K; Mayerl CJ; Gould FDH; Edmonds CE; Stricklen BM; Bond LE; German RZ, “Does birth weight affect neonatal body weight, growth, and physiology in an animal model?,” NEOMED Bibliography Database, accessed May 18, 2022, https://neomed.omeka.net/items/show/11586.

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