Review of fluconazole treatment and prophylaxis for invasive candidiasis in neonates.

Title

Review of fluconazole treatment and prophylaxis for invasive candidiasis in neonates.

Creator

Hornik CD; Bondi DS; Greene NM; Cober MP; John B

Publisher

Journal Of Pediatric Pharmacology & Therapeutics

Date

2021
2021-02

Description

Invasive candidiasis accounts for approximately 10% of nosocomial infections in preterm infants, with an incidence of 1% to 4% among neonatal intensive care unit (NICU) admissions and a mortality as high as 20% to 30%. These outcomes warrant improved treatment and prevention strategies for infants at highest risk. The Infectious Diseases Society of America provides guidelines on antifungal medications for the prophylaxis and treatment of candidiasis in NICUs; however, there are still variations in practice on the use of fluconazole for prophylaxis and treatment of invasive candidiasis. This review provides specific information regarding fluconazole activity, pharmacokinetics, and a literature evaluation of dosing strategies and comparisons to other treatments in the neonatal population. [ABSTRACT FROM AUTHOR]

Subject

amphotericin B; antifungal agents; Candida; candidiasis; DENTAL prophylaxis; fluconazole; FLUCONAZOLE; INVASIVE candidiasis; NEONATAL intensive care units; newborn; pharmacokinetics; PHARMACOKINETICS; PREMATURE infants

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

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Pages

115-122

Issue

2

Volume

26

ISSN

15516776

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Pharmacy Practice

Update Year & Number

April 2021 List

Citation

Hornik CD; Bondi DS; Greene NM; Cober MP; John B, “Review of fluconazole treatment and prophylaxis for invasive candidiasis in neonates.,” NEOMED Bibliography Database, accessed September 21, 2021, https://neomed.omeka.net/items/show/11646.

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