Bile acid metabolism and signaling.

Title

Bile acid metabolism and signaling.

Creator

Chiang John Y L

Publisher

Comprehensive Physiology

Date

2013
2013-07

Description

Bile acids are important physiological agents for intestinal nutrient absorption and biliary secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling molecules and metabolic regulators that activate nuclear receptors and G protein-coupled receptor (GPCR) signaling to regulate hepatic lipid, glucose, and energy homeostasis and maintain metabolic homeostasis. Conversion of cholesterol to bile acids is critical for maintaining cholesterol homeostasis and preventing accumulation of cholesterol, triglycerides, and toxic metabolites, and injury in the liver and other organs. Enterohepatic circulation of bile acids from the liver to intestine and back to the liver plays a central role in nutrient absorption and distribution, and metabolic regulation and homeostasis. This physiological process is regulated by a complex membrane transport system in the liver and intestine regulated by nuclear receptors. Toxic bile acids may cause inflammation, apoptosis, and cell death. On the other hand, bile acid-activated nuclear and GPCR signaling protects against inflammation in liver, intestine, and macrophages. Disorders in bile acid metabolism cause cholestatic liver diseases, dyslipidemia, fatty liver diseases, cardiovascular diseases, and diabetes. Bile acids, bile acid derivatives, and bile acid sequestrants are therapeutic agents for treating chronic liver diseases, obesity, and diabetes in humans.

Subject

Animals; Bile Acids and Salts/*metabolism/therapeutic use; Biliary Tract Diseases/metabolism; Cholesterol/metabolism; Cytoplasmic and Nuclear/metabolism; Enterohepatic Circulation/physiology; Feedback; G-Protein-Coupled/metabolism; Homeostasis/physiology; Humans; Inflammation/metabolism; Liver/metabolism; Physiological/physiology; Receptors; Signal Transduction/*physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1191–1212

Issue

3

Volume

3

Citation

Chiang John Y L, “Bile acid metabolism and signaling.,” NEOMED Bibliography Database, accessed May 12, 2021, https://neomed.omeka.net/items/show/2997.

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