Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes.

Title

Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes.

Creator

Song Kwang-Hoon; Ellis Ewa; Strom Stephen; Chiang John Y L

Publisher

Hepatology (Baltimore, Md.)

Date

2007
2007-12

Description

UNLABELLED: Bile acid synthesis in the liver is regulated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1). Transcription of the CYP7A1 gene is inhibited by bile acids and cytokines. The rate of bile acid synthesis is reduced immediately after partial hepatectomy and during the early stage of liver regeneration. Hepatocyte growth factor (HGF) released from stellate cells activates a receptor tyrosine kinase c-Met, in hepatocytes and stimulates signaling pathways that regulate cell growth, proliferation, and apoptosis. This study demonstrated that HGF strongly and rapidly repressed CYP7A1 mRNA expression and the rate of bile acid synthesis in primary human hepatocytes. HGF rapidly induced c-Jun and small heterodimer partner mRNA and protein expression and increased phosphorylation of ERK1/2, JNK, and c-Jun. Specific inhibitors of protein kinase C, extracellular signal-regulated kinase 1/2 (ERK1/2), and c-Jun

Subject

Bile Acids and Salts/*biosynthesis; Cells; Cholesterol 7-alpha-Hydroxylase/*biosynthesis; Cultured; Hepatocyte Growth Factor/*metabolism; Hepatocytes/*metabolism; Humans; Signal Transduction

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1993–2002

Issue

6

Volume

46

Citation

Song Kwang-Hoon; Ellis Ewa; Strom Stephen; Chiang John Y L, “Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes.,” NEOMED Bibliography Database, accessed April 23, 2021, https://neomed.omeka.net/items/show/3006.

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