Mechanisms of Gene-Environment Interactions in Parkinson's Disease.

Title

Mechanisms of Gene-Environment Interactions in Parkinson's Disease.

Creator

Fleming Sheila M

Publisher

Current environmental health reports

Date

2017
2017-06

Description

PURPOSE OF REVIEW: The purpose of the study was to discuss the main mechanisms associated with environmental and genetic factors that contribute to the development of Parkinson's disease (PD). RECENT FINDINGS: Novel genetic contributors to PD are being identified at a rapid pace in addition to novel environmental factors. The discovery of mutations in alpha-synuclein and leucine-rich repeat kinase 2 causing inherited forms of PD along with epidemiological, in vitro, and in vivo studies identifying herbicides, pesticides, and metals as risk factors have dramatically improved our understanding of mechanisms involved in the development of PD. However, at the same time, these discoveries have also added layers of complexity to the disease. Within the last several years, the genetics associated with PD has dominated the field in many ways; however, the majority of PD cases are likely due to different combinations of environmental exposures and genetic susceptibility. The most common toxicants used to model PD including rotenone, paraquat, and

Subject

*Alpha-synuclein; *ATP13A2; *Gene-Environment Interaction; *Genetic Predisposition to Disease; *Manganese; *Paraquat; *Parkinson Disease; *Parkinson's disease; *Rotenone; Environmental Exposure/*adverse effects; Herbicides/adverse effects; Humans; Insecticides/adverse effects; Mutation/genetics; Paraquat/adverse effects; Risk Factors; Rotenone/adverse effects

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

192–199

Issue

2

Volume

4

Citation

Fleming Sheila M, “Mechanisms of Gene-Environment Interactions in Parkinson's Disease.,” NEOMED Bibliography Database, accessed January 25, 2021, https://neomed.omeka.net/items/show/3277.

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