Frailty and subclinical coronary atherosclerosis: The Multicenter AIDS Cohort Study (MACS).

Frailty and subclinical coronary atherosclerosis: The Multicenter AIDS Cohort Study (MACS).

Korada Sai Krishna C; Zhao Di; Tibuakuu Martin; Brown Todd T; Jacobson Lisa P; Guallar Eliseo; Bolan Robert K; Palella Frank J; Margolick Joseph B; Martinson Jeremy J; Budoff Matthew J; Post Wendy S; Michos Erin D

Atherosclerosis

2017

2017-11

BACKGROUND AND AIMS: Frailty and cardiovascular disease share many risk factors. We evaluated whether frailty is independently associated with subclinical coronary atherosclerosis and whether any relationships differ by HIV-serostatus. METHODS: We studied 976 [62% HIV-infected] male participants of the Multicenter AIDS Cohort Study who underwent assessment of frailty and non-contrast cardiac CT scanning; of these, 747 men also underwent coronary CT angiography (CCTA). Frailty was defined as having \textgreater/=3 of 5 of the following: weakness, slowness, weight loss, exhaustion, and low physical activity. Coronary artery calcium (CAC) was assessed by non-contrast CT, and total plaque score (TPS), mixed plaque score (MPS), and non-calcified plaque score (NCPS) by CCTA. Multivariable-adjusted regression was used to assess the cross-sectional associations between frailty and subclinical coronary atherosclerosis. RESULTS: Mean (SD) age of participants was 54 (7) years; 31% were black. Frailty existed in 7.5% and 14.3% of

Acquired Immunodeficiency Syndrome/diagnosis/*epidemiology; Asymptomatic Diseases; Atherosclerotic; Cardiac CT; Computed Tomography Angiography; Coronary Angiography/methods; Coronary artery calcium; Coronary Artery Disease/diagnostic imaging/*epidemiology; Coronary atherosclerosis; Cross-Sectional Studies; Exercise; Frailty; Frailty/diagnosis/*epidemiology/physiopathology; Health Status; HIV-Infection; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Muscle Strength; Muscle Weakness; Plaque; Prevalence; Prognosis; Risk Factors; United States/epidemiology; Vascular Calcification/diagnostic imaging/*epidemiology; Weight Loss

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