3-D-QSAR and docking studies on the neuronal choline transporter.

3-D-QSAR and docking studies on the neuronal choline transporter.

Geldenhuys Werner J; Allen David D; Lockman Paul R

Bioorganic & medicinal chemistry letters

2010

2010-08

The high affinity neuronal choline transporter (CHT1) is responsible for the uptake of choline into the pre-synaptic terminal of cholinergic neurons. Considering our past experience with modeling the blood-brain barrier choline transporter (BBBCHT) as drug delivery vector to the CNS, we investigated the

Binding Sites; Blood-Brain Barrier/metabolism; Computer Simulation; Membrane Transport Proteins/*chemistry/metabolism; Models; Molecular; Neurons/*metabolism; Quantitative Structure-Activity Relationship; Quaternary Ammonium Compounds/chemistry

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4870–4877

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