3-D-QSAR and docking studies on the neuronal choline transporter.

Title

3-D-QSAR and docking studies on the neuronal choline transporter.

Creator

Geldenhuys Werner J; Allen David D; Lockman Paul R

Publisher

Bioorganic & medicinal chemistry letters

Date

2010
2010-08

Description

The high affinity neuronal choline transporter (CHT1) is responsible for the uptake of choline into the pre-synaptic terminal of cholinergic neurons. Considering our past experience with modeling the blood-brain barrier choline transporter (BBBCHT) as drug delivery vector to the CNS, we investigated the

Subject

Binding Sites; Blood-Brain Barrier/metabolism; Computer Simulation; Membrane Transport Proteins/*chemistry/metabolism; Models; Molecular; Neurons/*metabolism; Quantitative Structure-Activity Relationship; Quaternary Ammonium Compounds/chemistry

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

4870–4877

Issue

16

Volume

20

Citation

Geldenhuys Werner J; Allen David D; Lockman Paul R, “3-D-QSAR and docking studies on the neuronal choline transporter.,” NEOMED Bibliography Database, accessed June 17, 2021, https://neomed.omeka.net/items/show/3491.

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