Projections from auditory cortex contact ascending pathways that originate in the superior olive and inferior colliculus.

Title

Projections from auditory cortex contact ascending pathways that originate in the superior olive and inferior colliculus.

Creator

Peterson Diana Coomes; Schofield Brett R

Publisher

Hearing research

Date

2007
2007-10

Description

The superior olivary complex (SOC) and inferior colliculus (IC) are targets of cortical projections as well as sources of major ascending auditory pathways. This study examines whether the cortical projections contact cells in the SOC or IC that project to higher levels. First, we placed an anterograde tracer into the auditory cortex to label cortico-olivary axons and a retrograde tracer into the IC to label olivocollicular cells in guinea pigs. Cortical axons contacted many labeled cells in the ipsilateral SOC and fewer labeled cells in the contralateral SOC. Contacted cells projected to the ipsilateral or contralateral IC. In a second experiment, we labeled corticocollicular axons with an anterograde tracer and injected retrograde tracers into the medial geniculate (MG) to label colliculogeniculate cells. In the IC ipsilateral to the cortical injection, many cortical axons contacted colliculogeniculate cells in the dorsal cortex and external cortex of the IC. The contacted cells projected to the ipsilateral MG or, less often, to the contralateral MG. The results indicate that cortical projections are likely to contact cells in the SOC and IC that project to higher centers. This suggests that auditory cortex can modulate the ascending auditory pathways at multiple levels of the brainstem.

Subject

Animals; Auditory Cortex/*cytology; Auditory Pathways/*cytology; Fluorescence; Guinea Pigs; Inferior Colliculi/*cytology; Microscopy; Olivary Nucleus/*cytology; Staining and Labeling/methods

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

67–77

Issue

1

Volume

232

Citation

Peterson Diana Coomes; Schofield Brett R, “Projections from auditory cortex contact ascending pathways that originate in the superior olive and inferior colliculus.,” NEOMED Bibliography Database, accessed May 14, 2021, https://neomed.omeka.net/items/show/3579.

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