Changes in BiP (GRP78) levels upon HSV-1 infection are strain dependent.

Changes in BiP (GRP78) levels upon HSV-1 infection are strain dependent.

Mao H; Palmer D; Rosenthal K S

Virus research

2001

2001-08

BiP (grp78) is a chaperone protein which can also regulate the unfolded protein response of the cell. Levels of BiP increased in cells infected by the small plaque producing, cell associated, neuroinvasive strains of HSV-1 (SP7, 490) but decreased in cells infected with KOS, a large plaque, attenuated strain. BiP protein synthesis continued early in infection and BiP was sequestered and its degradation was limited during SP7 infection. BiP protein synthesis stopped and the protein was degraded in KOS infected cells. These viral strain dependent differences in BiP concentration may influence other aspects of the viral interaction with the target cell and its host.

3T3 Cells; Animals; Carrier Proteins/*biosynthesis/genetics; Heat-Shock Proteins/*biosynthesis/genetics; Herpesvirus 1; Human/isolation & purification/*physiology; Humans; Messenger/metabolism; Mice; Molecular Chaperones/*biosynthesis/genetics; RNA

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

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