Lack of Association Between Dexamethasone and Long-Term Survival After Non-Small Cell Lung Cancer Surgery.

Title

Lack of Association Between Dexamethasone and Long-Term Survival After Non-Small Cell Lung Cancer Surgery.

Creator

Cata Juan P; Jones Justin; Sepesi Boris; Mehran Reza J; Rodriguez-Restrepo Andrea; Lasala Javier; Feng Lei; Gottumukkala Vijaya

Publisher

Journal of cardiothoracic and vascular anesthesia

Date

2016
2016-08

Description

OBJECTIVE: To evaluate the association between the use of intraoperative dexamethasone with an increase in recurrence-free survival (RFS) and overall survival (OS) after non-small cell lung cancer (NSCLC) surgery. DESIGN: This was a propensity score-matched (PSM) retrospective study. SETTING: Single academic center. PARTICIPANTS: The study comprised patients with stage I through IIIa NSCLC. Patients were excluded if they were younger than 18 years, had missing data, and died within 30 days after surgery. MEASUREMENTS AND MAIN RESULTS: Primary outcomes of the study were RFS and OS. The data were PSM. RFS and OS were evaluated using univariate and multivariate Cox proportional hazards models after PSM to assess the association between intraoperative dexamethasone use and the primary outcomes. A p value of\textless0.05 was considered statistically significant. After PSM, 436 patients were included in each treatment group. Adjusting for significant covariates, the multivariate analysis demonstrated no association between the use of dexamethasone and RFS (hazard ratio [95% confidence interval]: 0.98 [0.78-1.24]; p = 0.915). The multivariate analysis also demonstrated no association between the administration of dexamethasone and OS (hazard ratio [95% confidence interval]: 1.08 [0.81-1.44]; p = 0.58). CONCLUSIONS: This study demonstrated that intraoperative dexamethasone administration to NSCLC patients was not associated with a significant impact on RFS and OS. The results were similar to a previous study on ovarian cancer patients. A randomized controlled study should be conducted to confirm the results of this study.

Subject

Aged; Anti-Inflammatory Agents/*administration & dosage; Carcinoma; dexamethasone; Dexamethasone/*administration & dosage; Female; Humans; Kaplan-Meier Estimate; long-term survival; Lung Neoplasms/mortality/*surgery; Male; Middle Aged; non-small cell lung cancer surgery; Non-Small-Cell Lung/mortality/*surgery; Propensity Score; Proportional Hazards Models; Retrospective Studies; Treatment Outcome

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

930–935

Issue

4

Volume

30

Citation

Cata Juan P; Jones Justin; Sepesi Boris; Mehran Reza J; Rodriguez-Restrepo Andrea; Lasala Javier; Feng Lei; Gottumukkala Vijaya, “Lack of Association Between Dexamethasone and Long-Term Survival After Non-Small Cell Lung Cancer Surgery.,” NEOMED Bibliography Database, accessed May 11, 2021, https://neomed.omeka.net/items/show/4031.

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