Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium.

Title

Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium.

Creator

Szilagyi John T; Mishin Vladimir; Heck Diane E; Jan Yi-Hua; Aleksunes Lauren M; Richardson Jason R; Heindel Ned D; Laskin Debra L; Laskin Jeffrey D

Publisher

Toxicological sciences : an official journal of the Society of Toxicology

Date

2016
2016-05

Description

Cytochrome P450 (CYP) enzymes mediate mixed-function oxidation reactions important in drug metabolism. The aromatic heterocyclic cation, diphenyleneiodonium (DPI), binds flavin in cytochrome P450 reductase and inhibits

Subject

*cytochrome P450; *flavoenzymes; *heme; *nitric oxide synthase; *reactive oxygen species; Animals; Cytochrome P-450 Enzyme Inhibitors/*pharmacology; Cytochrome P-450 Enzyme System/*metabolism; Dose-Response Relationship; Drug; Heme/*antagonists & inhibitors/metabolism; Humans; Liver/drug effects/enzymology; Mice; Microsomes; Nitric Oxide Synthase Type II/*antagonists & inhibitors/metabolism; Nitric Oxide/metabolism; Onium Compounds/*pharmacology; Rats; Recombinant Proteins/metabolism; Sprague-Dawley; Time Factors

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

150–159

Issue

1

Volume

151

Citation

Szilagyi John T; Mishin Vladimir; Heck Diane E; Jan Yi-Hua; Aleksunes Lauren M; Richardson Jason R; Heindel Ned D; Laskin Debra L; Laskin Jeffrey D, “Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium.,” NEOMED Bibliography Database, accessed December 6, 2021, https://neomed.omeka.net/items/show/4210.

Social Bookmarking