Longitudinal assessment of bone growth and development in a facility-based population of young adults with cerebral palsy.

Title

Longitudinal assessment of bone growth and development in a facility-based population of young adults with cerebral palsy.

Creator

Grossberg Richard; Blackford Martha G; Kecskemethy Heidi H; Henderson Richard; Reed Michael D

Publisher

Developmental medicine and child neurology

Date

2015
2015-11

Description

AIM: Osteoporosis is a significant clinical problem in persons with moderate to severe cerebral palsy (CP), causing fractures with minimal trauma. Over the past decade, most studies examining osteoporosis and CP have been cross-sectional in nature, focused exclusively on children and adolescents and only involving one evaluation of bone mineral density (BMD). The purpose of this study was to assess BMD in a group including adults with CP, and changes in each individual's BMD over a 5- to 6-year period. METHOD: The study group included 40 residents of a long-term care facility aged 6 to 26 years at the time of their initial evaluation. Twenty-one patients (52.5%) were male, 35 (88%) were white, and 38 (95%) were in Gross Motor Function Classification System level V. BMD was assessed by dual-energy X-ray absorptiometry on the right and left distal femurs for three distinct regions of interest. RESULTS: Five residents had a fracture that occurred during the study period; this represented a fracture rate of 2.1% per year in the study group. Longitudinally, annualized change in the median BMD was 0.7% to 1.0% per year in the different regions of the distal femur, but ranged widely among the study group, with both increases and decreases in BMD. Increase in BMD over time was negatively correlated with age and positively correlated with change in weight. INTERPRETATION: Changes in BMD over time in profoundly involved persons with CP can range widely, which is important to recognize when evaluating potential interventions to improve BMD. Age and changes in body weight appear the most relevant factors.

Subject

Absorptiometry; Adolescence; Adolescent; Adult; Bone Density – Physiology; Bone Density/*physiology; Cerebral Palsy – Physiopathology; Cerebral Palsy/*physiopathology; Child; Cross Sectional Studies; Cross-Sectional Studies; Female; Human; Humans; Long Term Care – Statistics and Numerical Data; Long-Term Care/*statistics & numerical data; Longitudinal Studies; Male; Photon; Preschool; Prospective Studies; Risk Factors; Young Adult

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1064–1069

Issue

11

Volume

57

Citation

Grossberg Richard; Blackford Martha G; Kecskemethy Heidi H; Henderson Richard; Reed Michael D, “Longitudinal assessment of bone growth and development in a facility-based population of young adults with cerebral palsy.,” NEOMED Bibliography Database, accessed September 23, 2021, https://neomed.omeka.net/items/show/4443.

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