Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.

Title

Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.

Creator

Chiang John Y L

Publisher

American journal of physiology. Gastrointestinal and liver physiology

Date

2003
2003-03

Description

Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Recent studies reveal that bile acids also are signaling molecules that activate several nuclear receptors and regulate many physiological pathways and processes to maintain bile acid and cholesterol homeostasis. Mutations of the principal regulatory genes in bile acid biosynthetic pathways have recently been identified in human patients with hepatobiliary and cardiovascular diseases. Genetic manipulation of key regulatory genes and bile acid receptor genes in mice have been obtained. These advances have greatly improved our understanding of the molecular mechanisms underlying complex liver physiology but also raise many questions and controversies to be resolved. These developments will lead to early diagnosis and discovery of drugs for treatment of liver and cardiovascular diseases.

Subject

Animals; Bile Acids and Salts/biosynthesis/genetics/*physiology; Bile/*physiology; Cardiovascular Diseases/genetics/physiopathology; Cholesterol/physiology; Cytoplasmic and Nuclear/*physiology; Feedback/physiology; Gene Expression Regulation/physiology; Humans; Liver Diseases/genetics/physiopathology; Liver/*physiology; Receptors

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

G349–356

Issue

3

Volume

284

Citation

Chiang John Y L, “Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.,” NEOMED Bibliography Database, accessed October 23, 2021, https://neomed.omeka.net/items/show/4590.

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