Comparison of anorectic drugs in rats trained to discriminate between satiation and deprivation.

Title

Comparison of anorectic drugs in rats trained to discriminate between satiation and deprivation.

Creator

Schechter M D

Publisher

Life sciences

Date

1990
1905-06

Description

Eight male rats were trained to discriminate between the internal states produced by food deprivation of 3 hours (satiation) and that produced by food deprivation of 27 hours duration (deprivation). One lever, in a two-lever operant chamber, had to be pressed to receive reinforcement in the satiation state, whereas pressing the other lever was required when the rat was in the deprivation state. Once the rats were trained, increasing the number of hours of food deprivation, from 1 to 48 hours, resulted in more deprivation-appropriate lever responses in the two-lever operant task. Administration of doses of fenfluramine (0.5-1.5 mg.kg), its active metabolite norfenfluramine (0.25-1.0 mg/kg) or d-amphetamine (0.5-1.5 mg/kg) produced a dose-responsive decrease in deprivation-appropriate responses when each drug/dose was injected (i.p.) 15 min prior to deprivation (27 hours) testing. Norfenfluramine was 1.5 times more potent than fenfluramine which was 1.5 times more potent than amphetamine.

Subject

Male; Animals; Rats; Analysis of Variance; Discrimination Learning/*drug effects; Amphetamine/*pharmacology; *Food Deprivation; Fenfluramine/*analogs & derivatives/*pharmacology; Norfenfluramine/*pharmacology; Satiation/*drug effects; Dose-Response Relationship; Drug; Inbred Strains

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

17–24

Issue

1

Volume

47

Citation

Schechter M D, “Comparison of anorectic drugs in rats trained to discriminate between satiation and deprivation.,” NEOMED Bibliography Database, accessed April 21, 2021, https://neomed.omeka.net/items/show/5614.

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