A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.

Title

A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.

Creator

Yamamoto B K; Pehek E A

Publisher

Brain research

Date

1990
1990-01

Description

The neurochemical heterogeneity of the rat striatum was assessed in vivo by measuring subregional changes in extracellular dopamine and DOPAC by in vivo electrochemistry and microdialysis in response to amphetamine and the D2 antagonist, (-)-sulpiride. Both in vivo electrochemical and microdialysis experiments indicated a significant rostrocaudal gradient in dopamine release following amphetamine. The increase in dopamine release was highest in the rostral areas (over 800% of baseline values) and lowest in the most caudal subregion (425% of baseline). No lateromedial differences in dopamine release were observed. DOPAC levels decreased in dialysates but were similar for all 6 subregions examined. In contrast, D2 blockade with (-)-sulpiride revealed a lateromedial gradient in the increases seen for dopamine and DOPAC such that greater increases were observed in the lateral subregions. (-)-Sulpiride did not produce any differential effects along the rostrocaudal axis. The regional gradients detected in extracellular fluid changes of dopamine and DOPAC indicate that dopamine release is locally regulated by an interaction between the density of dopaminergic innervation to a particular subregion and the D2 receptor density.

Subject

Male; Animals; Rats; Dopamine/*metabolism; Corpus Striatum/*metabolism; Amphetamines/*pharmacology; Electrochemistry; Sulpiride/*pharmacology; Inbred Strains; Receptors; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Dopamine/drug effects; Dopamine D2

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

236–242

Issue

2

Volume

506

Citation

Yamamoto B K; Pehek E A, “A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.,” NEOMED Bibliography Database, accessed June 13, 2021, https://neomed.omeka.net/items/show/5716.

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