Drug-induced acute renal failure: keys to recognizing and treating intrarenal toxicity.

Title

Drug-induced acute renal failure: keys to recognizing and treating intrarenal toxicity.

Creator

Frazee L A; Rutecki G W; Whittier F C

Publisher

Consultant (00107069)

Date

1997
1997-06

Description

Drug-induced acute tubular necrosis is a primary cause of acute renal failure (ARF); it may result from the use of such agents as aminoglycosides, amphotericin B, and radilocontrast media. To reduce the risk of aminoglycoside toxicity, prescribe the shortest course possible, use once-daily dosing, monitor serum concentrations, and avoid using these agents altogether in patients with known risk factors. Radiocontrast media-associated ARF is most likely to occur with preexisting renal damage, especially in a patient with diabetes mellitus. Since sodium depletion is the most important risk factor for nephrotoxic injury with amphotericin B use, saline loading is recommended both before and during drug administration. Drug-induced acute interstitial nephritis, another important cause of ARF, has been associated with a number of antibiotics, especially penicillin and ampicillin; many patients recover with the removal of the offending agent.

Subject

Adult; Female; Male; Aged; Risk Factors; Kidney Function Tests; Kidney Failure; Physiologic; Monitoring; Nephrotoxicity; Antiinflammatory Agents; Non-Steroidal – Adverse Effects; Acute – Chemically Induced; Acute – Diagnosis; Acute – Therapy; Aminoglycosides – Adverse Effects; Amphotericin B – Adverse Effects; Contrast Media – Adverse Effects; Drugs – Adverse Effects; Nephrotoxicity – Prevention and Control

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1592–1599

Issue

6

Volume

37

Citation

Frazee L A; Rutecki G W; Whittier F C, “Drug-induced acute renal failure: keys to recognizing and treating intrarenal toxicity.,” NEOMED Bibliography Database, accessed July 24, 2021, https://neomed.omeka.net/items/show/6141.

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