The additive effects of carnitine and ascorbic acid on distally burned dorsal skin flap in rats

The additive effects of carnitine and ascorbic acid on distally burned dorsal skin flap in rats

Arslan E; Basterzi Y; Aksoy A; Majka C; Unal S; Sari A; Demirkan F

Medical Science Monitor

2005

2005-06

Background: The purpose of this study was to determine the effects of combined use of L-carnitine and vitamin C on partially burned skin flap in an experimental rat model. Material/Methods: In the rat dorsal skin, a 10x3 cm flap was marked. The most distal 3x3 cm part was burned to full thickness. Twenty-four rats were randomized into four groups with 6 animals in each. Group 1 was simply followed tip. Group 2 was given 0.5 mg/kg vitamin C per day for 7 days, group 3 100 mg/kg carnitine per day for 7 days, and group 4 both carnitine and vitamin C. On the eighth postoperative day, the animals were sacrificed and examined. The surviving and necrotic areas were determined by macroscopic examination and measured with a planimeter. Results: The areas of flap necrosis were measured. The median surviving areas and areas of flap necrosis, respectively, of the groups were: group 1, 16.0 cm(2) and 14.0 cm(2); group 2, 18.25 cm(2) and 11.75 cm(2); group 3, 20.0 cm(2) and 10 cm(2); and group 4, 23.75 cm(2) and 6.25 cm(2). The surviving areas of the groups were found to be significantly different (p=0.000).

ischemia; prevention; ultrastructure; Research & Experimental Medicine; model; metabolism; skeletal-muscle; vitamin C; burn; carnitine; skin flap; thermal-injury

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Journal Article or Conference Abstract Publication

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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

BR176-BR180

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