Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration.

Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration.

Budge Kevin; Neal Matthew L; Richardson Jason R; Safadi Fayez F

Molecular neurobiology

2020

2020-05-20

Parkinson's disease (PD) is a progressive neurodegenerative disease highlighted by a marked loss of dopaminergic cell loss and motor disturbances. Currently, there are no drugs that slow the progression of the disease. A myriad of factors have been implicated in the pathogenesis and progression of PD including neuroinflammation. Although anti-inflammatory agents are being evaluated as potential disease-modifying therapies for PD, none has proven effective to date, suggesting that new and novel targets are needed. Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that has recently been shown to reduce inflammation in astrocytes and to be increased in post-mortem PD brain samples. Here we show that transgenic overexpression of GPNMB protects against dopaminergic neurodegeneration in a

GPNMB; Microglia; MPTP; Neuroinflammation; Neuroprotective; Parkinson's disease

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

journalArticle

1559-1182 0893-7648

NEOMED College of Medicine

NEOMED College of Pharmacy

Department of Anatomy & Neurobiology

Department of Pharmaceutical Sciences

June 2020 Update II