Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration.

Title

Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration.

Creator

Budge Kevin; Neal Matthew L; Richardson Jason R; Safadi Fayez F

Publisher

Molecular neurobiology

Date

2020
2020-05-20

Description

Parkinson's disease (PD) is a progressive neurodegenerative disease highlighted by a marked loss of dopaminergic cell loss and motor disturbances. Currently, there are no drugs that slow the progression of the disease. A myriad of factors have been implicated in the pathogenesis and progression of PD including neuroinflammation. Although anti-inflammatory agents are being evaluated as potential disease-modifying therapies for PD, none has proven effective to date, suggesting that new and novel targets are needed. Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that has recently been shown to reduce inflammation in astrocytes and to be increased in post-mortem PD brain samples. Here we show that transgenic overexpression of GPNMB protects against dopaminergic neurodegeneration in a

Subject

GPNMB; Microglia; MPTP; Neuroinflammation; Neuroprotective; Parkinson's disease

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

URL Address

http://doi.org/10.1007/s12035-020-01921-6

Search for Full-text

NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/s12035-020-01921-6

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ISSN

1559-1182 0893-7648

NEOMED College

NEOMED College of Medicine
NEOMED College of Pharmacy

NEOMED Department

Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences

Update Year & Number

June 2020 Update II

Citation

Budge Kevin; Neal Matthew L; Richardson Jason R; Safadi Fayez F, “Transgenic Overexpression of GPNMB Protects Against MPTP-Induced Neurodegeneration.,” NEOMED Bibliography Database, accessed September 12, 2024, https://neomed.omeka.net/items/show/11103.