Transient receptor potential vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH oxidase 4.

Title

Transient receptor potential vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH oxidase 4.

Creator

Al-Azzam N; Teegala LR; Pokhrel S; Ghebreigziabher S; Chachkovskyy T; Thodeti S; Gavilanes I; Covington K; Thodeti CK; Paruchuri S

Publisher

Scientific Reports

Date

2020
2020-06

Description

Asthma is characterized by pathological airway remodeling resulting from persistent myofibroblast activation. Although transforming growth factor beta 1 (TGFβ1), mechanical signals, and reactive oxygen species (ROS) are implicated in fibroblast differentiation, their integration is still elusive. We identified that Transient Receptor Potential Vanilloid 4 (TRPV4), a mechanosensitive ion channel mediates lung fibroblast (LF) differentiation and D. farinae-induced airway remodeling via a novel

Subject

ASTHMA; CAPSAICIN receptors; GROWTH factors; NICOTINAMIDE adenine dinucleotide phosphate; OXIDATION-reduction reaction; TRP channels

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Pages

9827

Issue

1

Volume

10

NEOMED College

NEOMED College of Medicine
NEOMED College of Medicine Student

NEOMED Department

Department of Integrative Medical Sciences
NEOMED Student Publications

Update Year & Number

July 2020 List

Citation

Al-Azzam N; Teegala LR; Pokhrel S; Ghebreigziabher S; Chachkovskyy T; Thodeti S; Gavilanes I; Covington K; Thodeti CK; Paruchuri S, “Transient receptor potential vanilloid channel regulates fibroblast differentiation and airway remodeling by modulating redox signals through NADPH oxidase 4.,” NEOMED Bibliography Database, accessed January 15, 2021, https://neomed.omeka.net/items/show/11142.

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