Gender differences in the association between antidepressant use and restless legs syndrome.
Title
Gender differences in the association between antidepressant use and restless legs syndrome.
Creator
Baughman Kristin R; Bourguet Claire C; Ober Scott K
Publisher
Movement disorders : official journal of the Movement Disorder Society
Date
2009
2009-05
Description
Contradictory results have been reported for the association between antidepressant use and Restless Legs Syndrome (RLS). Our aim was to clarify the relationship and examine possible gender differences. We interviewed 1,693 veterans receiving primary care from the Cleveland VA Medical Center and obtained prescription drug information from their medical records. Overall, use of an antidepressant was associated with RLS for men (RR = 1.77, CI = 1.26, 2.48) but not for women (RR = 0.79, CI = 0.43, 1.47). Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men. We conclude that RLS may be associated with antidepressant use, but the association varies by gender and type of antidepressant. Antidepressant use is more strongly associated with RLS in men than in women.
Subject
*Sex Characteristics; 80 and over; 80 and Over; Adult; Aged; Antidepressive Agents – Adverse Effects; Antidepressive Agents – Classification; Antidepressive Agents/*adverse effects/classification; Female; Human; Humans; Male; Middle Age; Middle Aged; Observation; Observational Methods; Primary Health Care – Statistics and Numerical Data; Primary Health Care/statistics & numerical data; Regression; Regression Analysis; Reproduction; Restless Legs – Chemically Induced; Restless Legs Syndrome/*chemically induced; Risk Factors; Veterans; Young Adult
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Baughman Kristin R; Bourguet Claire C; Ober Scott K, “Gender differences in the association between antidepressant use and restless legs syndrome.,” NEOMED Bibliography Database, accessed May 10, 2024, https://neomed.omeka.net/items/show/3079.