Gender differences in the association between antidepressant use and restless legs syndrome.

Title

Gender differences in the association between antidepressant use and restless legs syndrome.

Creator

Baughman Kristin R; Bourguet Claire C; Ober Scott K

Publisher

Movement disorders : official journal of the Movement Disorder Society

Date

2009
2009-05

Description

Contradictory results have been reported for the association between antidepressant use and Restless Legs Syndrome (RLS). Our aim was to clarify the relationship and examine possible gender differences. We interviewed 1,693 veterans receiving primary care from the Cleveland VA Medical Center and obtained prescription drug information from their medical records. Overall, use of an antidepressant was associated with RLS for men (RR = 1.77, CI = 1.26, 2.48) but not for women (RR = 0.79, CI = 0.43, 1.47). Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men. We conclude that RLS may be associated with antidepressant use, but the association varies by gender and type of antidepressant. Antidepressant use is more strongly associated with RLS in men than in women.

Subject

*Sex Characteristics; 80 and over; 80 and Over; Adult; Aged; Antidepressive Agents – Adverse Effects; Antidepressive Agents – Classification; Antidepressive Agents/*adverse effects/classification; Female; Human; Humans; Male; Middle Age; Middle Aged; Observation; Observational Methods; Primary Health Care – Statistics and Numerical Data; Primary Health Care/statistics & numerical data; Regression; Regression Analysis; Reproduction; Restless Legs – Chemically Induced; Restless Legs Syndrome/*chemically induced; Risk Factors; Veterans; Young Adult

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1054–1059

Issue

7

Volume

24

Citation

Baughman Kristin R; Bourguet Claire C; Ober Scott K, “Gender differences in the association between antidepressant use and restless legs syndrome.,” NEOMED Bibliography Database, accessed June 13, 2021, https://neomed.omeka.net/items/show/3079.

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