The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.

Title

The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.

Creator

Xu K; Dluzen D E

Publisher

Experimental neurology

Date

2000
2000-12

Description

We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion protocol permits us to focus upon the role of this neurotrophin as related to vesicular storage and release of dopamine (DA). The effects of two

Subject

*Nerve Growth Factors; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Dose-Response Relationship; Drug; Extracellular Space/metabolism; Glial Cell Line-Derived Neurotrophic Factor; Male; Microdialysis; Nerve Tissue Proteins/*pharmacology; Neuroprotective Agents/*pharmacology; Parkinson Disease/drug therapy/metabolism; Potassium/*pharmacology; Rats; Sprague-Dawley; Substantia Nigra/*drug effects/metabolism

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

450–457

Issue

2

Volume

166

Citation

Xu K; Dluzen D E, “The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.,” NEOMED Bibliography Database, accessed September 25, 2021, https://neomed.omeka.net/items/show/3114.

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