The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.
Title
The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.
Creator
Xu K; Dluzen D E
Publisher
Experimental neurology
Date
2000
2000-12
Description
We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion protocol permits us to focus upon the role of this neurotrophin as related to vesicular storage and release of dopamine (DA). The effects of two
Subject
*Nerve Growth Factors; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Dose-Response Relationship; Drug; Extracellular Space/metabolism; Glial Cell Line-Derived Neurotrophic Factor; Male; Microdialysis; Nerve Tissue Proteins/*pharmacology; Neuroprotective Agents/*pharmacology; Parkinson Disease/drug therapy/metabolism; Potassium/*pharmacology; Rats; Sprague-Dawley; Substantia Nigra/*drug effects/metabolism
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Xu K; Dluzen D E, “The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.,” NEOMED Bibliography Database, accessed September 27, 2023, https://neomed.omeka.net/items/show/3114.