The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat.

Title

The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat.

Creator

Schechter M D

Publisher

Psychopharmacology

Date

1995
1995-05

Description

The objective of this study was to train rats to discriminate the interoceptive stimuli produced by a selective dopamine D1 agonist. Fourteen male Sprague-Dawley rats acquired the discrimination of the fully effective, high potency, D1 agonist dihydrexidine (DHX) within 20 sessions using a training dose of 3.0 mg/kg. DHX (0.75-4.5 mg/kg) dose-dependently increased DHX-appropriate responding with an ED50 = 1.44 mg/kg. The selective D1 agonist SKF 38398 (2.0-8.0 mg/kg) dose-responsively generalized with an ED50 = 3.54 mg/kg; significantly less potent than DHX. The selective D1 antagonist SCH 23390 (0.06-0.12 mg/kg) dose-responsively decreased DHX-appropriate discriminative performance. These data would indicate that DHX is a selective D1 agonist that may allow for testing of the selectivity of other putative D1 agonists in this experimental procedure. Administration of non-selective dopaminergically active drugs, including apomorphine, amphetamine and cocaine, were each shown to produce intermediate

Subject

Amphetamine/pharmacology; Animals; Apomorphine/pharmacology; Benzazepines/pharmacology; Cocaine/pharmacology; Discrimination (Psychology); Dopamine Agonists/pharmacology; Dopamine D1/*agonists; Dose-Response Relationship; Drug; Male; Phenanthridines/*pharmacology; Rats; Receptors; Sprague-Dawley

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

79–84

Issue

1

Volume

119

Citation

Schechter M D, “The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat.,” NEOMED Bibliography Database, accessed December 9, 2021, https://neomed.omeka.net/items/show/3152.

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